“jwh 073”的搜索结果

产品 1 到 50 共 127个

每页
页面:
  1. 1
  2. 2
  3. 3

设置降序顺序
  1. AMG 073 (Cinacalcet)

    Catalog No. A11314
    Quick View
    CaSR activator
    AMG 073 (Cinacalcet)是一类治疗甲状旁腺功能亢进的新型化合物。 了解更多
  2. AMG-073 HCl (Cinacalcet HCl)

    Catalog No. A10219
    Quick View
    CaSR activator
    AMG-073 HCl(Cinacalcet HCl)是一种用于治疗甲状旁腺功能亢进的化合物,称为拟钙剂,通过增加甲状旁腺钙敏感受体(CaR)对细胞外钙的敏感性来减少甲状旁腺激素(PTH)的合成和分泌 。 了解更多
  3. Pocapavir (SCH-48973)

    Catalog No. A18331
    Quick View
    EV capsid inhibitor
    Pocapavir is an investigational enterovirus (EV) capsid inhibitor. 了解更多
  4. Fluxapyroxad

    Catalog No. A22073
    Quick View
    the succinate dehydrogenase (SQR) enzyme inhibitor
    Fluxapyroxad, a broad-spectrum fungicide, is an inhibitor of the succinate dehydrogenase (SQR) enzyme. 了解更多
  5. MB-07344

    Catalog No. A20748
    Quick View
    TR-β agonist
    MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM. 了解更多
  6. NI-57

    Catalog No. A20739
    Quick View
    BRPF inhibitor
    NI-57 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively. 了解更多
  7. Duocarmycin MA

    Catalog No. A20738
    Quick View
    antibody drug conjugates (ADCs) toxin
    Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. 了解更多
  8. GSK864

    Catalog No. A20737
    Quick View
    IDH1 mutant inhibitor
    GSK864 is an isocitrate dehydrogenase 1 (IDH1) mutant inhibitor; inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM. 了解更多
  9. GSK180736A

    Catalog No. A20736
    Quick View
    GRK2 inhibitor
    GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM. 了解更多
  10. JAK3-IN-1

    Catalog No. A20734
    Quick View
    JAK3 inhibitor
    JAK3-IN-1 is a potent JAK3 inhibitor with IC50 of 4.8 nM, also inhibits JAK1 (IC50 = 896 nM) and JAK2 (IC50 = 1050 nM). 了解更多
  11. Fenclozine

    Catalog No. A20733
    Quick View
    Fenclozine is a non-steroidal antiinflammatory drug extracted from patent WO 2012112690 A2. 了解更多
  12. JNJ-46778212

    Catalog No. A20732
    Quick View
    mGlu5 positive allosteric modulator
    JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. 了解更多
  13. CV-159

    Catalog No. A20731
    Quick View
    dihydropyridine Ca2+ antagonist
    CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities. 了解更多
  14. SBI-0640756

    Catalog No. A20730
    Quick View
    eIF4G1 inhibitor
    SBI-0640756 (SBI-756) is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex. 了解更多
  15. SB-772077B dihydrochloride

    Catalog No. A20090
    Quick View
    ROCK inhibitor
    SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively. 了解更多
  16. Grp94 Inhibitor-1

    Catalog No. A20073
    Quick View
    Grp94 inhibitor
    Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α. 了解更多
  17. AZ10606120 dihydrochloride

    Catalog No. A19853
    Quick View
    P2X7R antagonist
    AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10?nM. 了解更多
  18. Acetylazide

    Catalog No. A19370
    Quick View
    Acetylazide is a synthetic broad-spectrum bacteriostatic antibiotic. 了解更多
  19. MB-07811

    Catalog No. A19325
    Quick View
    MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity. 了解更多
  20. ABL127

    Catalog No. A19208
    Quick View
    PME-1 inhibitor
    ABL127 is a selective and covalent inhibitor of protein methylesterase 1 (PME-1) with IC50s of 6.4 nM and 4.2 nM in HEK293T and MDA-MB-231 cells, respectively. 了解更多
  21. DM4

    Catalog No. A21440
    Quick View
    DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. 了解更多
  22. Defactinib hydrochloride

    Catalog No. A22003
    Quick View
    FAK inhibitor
    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多
  23. Defactinib

    Catalog No. A21958
    Quick View
    FAK inhibitor
    Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. 了解更多
  24. ELX-02 sulfate

    Catalog No. A21764
    Quick View
    ELX-02 sulfate (NB-124 sulfate) is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). ELX-02 sulfate is being developed as a therapy for genetic diseases caused by nonsense mutations. 了解更多
  25. Gosogliptin

    Catalog No. A21566
    Quick View
    DPP-IV inhibitor
    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). 了解更多
  26. 5'-GTP trisodium salt hydrate

    Catalog No. A21514
    Quick View
    signal transducing G proteins activator
    5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. 了解更多
  27. Ralinepag

    Catalog No. A21073
    Quick View
    IP receptor agonist
    Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. 了解更多
  28. B-Raf IN 1

    Catalog No. A21055
    Quick View
    B-Raf kinase inhibitor
    B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多
  29. Cenerimod

    Catalog No. A20913
    Quick View
    S1P1 agonist
    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. 了解更多
  30. Loxapine

    Catalog No. A18073
    Quick View
    D2DR/D4DR inhibitor
    Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. 了解更多
  31. Cabozantinib S-malate

    Catalog No. A11349
    Quick View
    multiple receptor tyrosine kinases inhibitor
    Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. 了解更多
  32. RPR107393 free base

    Catalog No. A13051
    Quick View
    squalene synthase inhibitor
    RPR107393 free base is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC50 of 0.8??0.2 nM. 了解更多
  33. PSI-7409

    Catalog No. A13962
    Quick View
    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多
  34. Lenampicillin hydrochloride

    Catalog No. A13686
    Quick View
    Lenampicillin (hydrochloride) is the efficient prodrug of ampicillin (ABPC ) in terms of the enhancement of absorption and decrease of side effects. 了解更多
  35. TD-0212

    Catalog No. A13715
    Quick View
    neprilysin (NEP) inhibitor
    TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. 了解更多
  36. Demethoxydeacetoxypseudolaric acid B analog

    Catalog No. A18986
    Quick View
    Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM. 了解更多
  37. E3 ligase Ligand 10

    Catalog No. A19045
    Quick View
    E3 ubiquitin ligase ligand
    E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. 了解更多
  38. GSK547

    Catalog No. A19073
    Quick View
    RIP1 inhibitor
    GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. 了解更多
  39. BN82002

    Catalog No. A19386
    Quick View
    CDC25 phosphatase family inhibitor
    BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. 了解更多
  40. LY223982

    Catalog No. A19436
    Quick View
    LTB4 receptor inhibitor
    LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. 了解更多
  41. SBC-110736

    Catalog No. A20151
    Quick View
    PCSK9 inhibitor
    SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1. 了解更多
  42. ZT-12-037-01

    Catalog No. A18395
    Quick View
    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 了解更多
  43. MI-1061

    Catalog No. A18450
    Quick View
    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. 了解更多
  44. BC-1215

    Catalog No. A18605
    Quick View
    FBXO3 inhibitor
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. 了解更多
  45. Lincomycin Hydrochloride Monohydrate

    Catalog No. A17584
    Quick View
    Antibacterial agent
    Lincomycin hydrochloride is a peptidyl transferase and protein translation inhibitor used to treat bacterial infections. It also inhibits growth of plasmodium. 了解更多
  46. Pamiparib

    Catalog No. A17073
    Quick View
    PARP 抑制剂
    Pamiparib也称为BGB-290,是一种高效的,选择性的PARP抑制剂,具有良好的药物代谢和药代动力学特性。 了解更多
  47. CY-09

    Catalog No. A16924
    Quick View
    NLRP3 抑制剂
    CY-09是NLRP3抑制剂,Kd值为500 nM。它直接与NLRP3 NACHT域的ATP结合基序结合。 了解更多
  48. H9N2 Hong-Kong

    Catalog No. AP6213
    Quick View
    H9N2 Influenza-A Virus Hong-Kong/1073/99 Recombinant 了解更多
  49. HCV Core Genotype-5

    Catalog No. AP6073
    Quick View
    Hepatitis C Virus Core Genotype-5 Recombinant 了解更多
  50. MIG Human

    Catalog No. AP5717
    Quick View
    MIG Human Recombinant (CXCL9) 了解更多

产品 1 到 50 共 127个

每页
页面:
  1. 1
  2. 2
  3. 3

设置降序顺序
Rewards