MEK

Catalog No.Inhibitor Name MEKMEK1MEK1/2MEK2MEK5Other
A10257Selumetinib
***
A10256PD0325901
****
A11029Trametinib
****
****
A10957U0126-EtOH
*
**
MKK6/p38 MAPK,MKK3/p38 MAPK
A10212PD184352
**
**
A10705PD98059
*
A10151BIX 02189
****
ERK5,TGFβR1
A10089Pimasertib
*
A10150BIX 02188
***
ERK5,TGFβR1
A11040TAK-733
****
A10115AZD8330
ERK phosphorylation
A11493Binimetinib
***
***
A14137SL-327
*
*
AP-1,MKK3/p38 MAPK
A11264Refametinib
**
**
A12974GDC-0623
****
A15762BI-847325
**
***
Aurora B,Aurora C,Aurora A
A11441Cobimetinib
***
A10704PD318088
A10453Honokiol
Akt-phosphorylation
A11247RO4927350
A13272RO4987655
****
A14019RO5126766 (CH5126766)
*
BRAF, CRAF

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. RO5126766 (CH5126766)

    Catalog No. A14019
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    Raf/MEK dual 抑制剂
    RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶(MAPK)具有特异性的蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多

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