MEK

Catalog No.Inhibitor Name MEKMEK1MEK1/2MEK2MEK5Other
A10257Selumetinib
***
A10256PD0325901
****
A11029Trametinib
****
****
A10957U0126-EtOH
*
**
MKK6/p38 MAPK,MKK3/p38 MAPK
A10212PD184352
**
**
A10705PD98059
*
A10151BIX 02189
****
ERK5,TGFβR1
A10089Pimasertib
*
A10150BIX 02188
***
ERK5,TGFβR1
A11040TAK-733
****
A10115AZD8330
ERK phosphorylation
A11493Binimetinib
***
***
A14137SL-327
*
*
AP-1,MKK3/p38 MAPK
A11264Refametinib
**
**
A12974GDC-0623
****
A15762BI-847325
**
***
Aurora B,Aurora C,Aurora A
A11441Cobimetinib
***
A10704PD318088
A10453Honokiol
Akt-phosphorylation
A11247RO4927350
A13272RO4987655
****
A14019RO5126766 (CH5126766)
*
BRAF, CRAF

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BIX 02189

    Catalog No. A10151
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    MEK 抑制剂
    BIX 02189是选择性双重MEK5和ERK5(或BMK1)激酶抑制剂,对于MEK5,ERK5,TGFbR1和其他紧密相关的激酶,IC50值分别为1.5、59、580和> 6200 nM。 了解更多
  2. BIX02188

    Catalog No. A10150
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    MEK5 抑制剂
    BIX02188是一种有效的选择性MEK5抑制剂。 了解更多

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