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MK-4305 (Suvorexant)

促销

OX receptor 拮抗剂

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产品目录号: A11500

库存状态:中国现货中国现货

产品名 目录号 价格 数量
MK-4305 (Suvorexant) 5mg A11500-5
¥ 900.00
MK-4305 (Suvorexant) 10mg A11500-10
¥ 1,600.00
MK-4305 (Suvorexant) 25mg A11500-25
¥ 3,500.00
MK-4305 (Suvorexant) 50mg A11500-50
¥ 6,000.00
MK-4305 (Suvorexant) 10mM * 1mL in DMSO A11500-10mM-D
¥ 1,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.

MK-4305 (Suvorexant)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 MK-4305 (Suvorexant) 发表的文献 (6)
  • Obara K, .et al. Assessment of Inhibitory Effects of Hypnotics on Acetylcholine-Induced Contractions in Isolated Rat Urinary Bladder Smooth Muscle, Biol Pharm Bull, 2019, 42(2):280-288 PMID: 30713259
  • James B Jaggard, .et al. Hypocretin underlies the evolution of sleep loss in the Mexican cavefish, eLife, 2018, 7: e32637 PMID: 29405117
  • Skillman B, .et al. Quantification of suvorexant in blood using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2018, Aug 1;1091:87-95 PMID: 29859493
  • Clark L, .et al. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies, J Biomol NMR, 2018, Aug;71(4):203-211 PMID: 30121871
  • Sullinger S, .et al. Identification of Suvorexant in Urine Using Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry (LC-Q/TOF-MS), J Anal Toxicol, 2017, Apr 1;41(3):224-229 PMID: 28035034
  • Carson M, .et al. Quantification of suvorexant in urine using gas chromatography/mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 2017, Jan 1;1040:289-294 PMID: 27825624

Chemical Information

目录号 A11500
Mechanism of action Antagonist
分子量 450.92
化学分子式 C23H23ClN6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1030377-33-3
Synonyms MK4305, MK 4305
SMILES code C[C@@H]1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
化学名称 5-Chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole

生物活性

Description
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
Targets
OX2 receptor OX1 receptor
0.35 nM(Ki)0.55 nM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 10 mg/mL (22.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.18 mL 110.88 mL 221.77mL
0.5 mM 4.44 mL 22.18 mL 44.35 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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