MK-4305 (Suvorexant)

目录号: A11500

OX receptor antagonist

MK-4305 (Suvorexant)

MK-4305 (Suvorexant) Chemical Structure

CAS NO. 1030377-33-3

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
25 mg
¥ 3,500.00
50 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 1,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.
Targets
OX2 receptor OX1 receptor
0.35 nM(Ki)0.55 nM(Ki)
In vitro DMSO 10 mg/mL (22.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.18 mL 110.88 mL 221.77 mL
0.5 mM 4.44 mL 22.18 mL 44.35 mL
1 mM 2.22 mL 11.09 mL 22.18 mL
5 mM 0.44 mL 2.22 mL 4.44 mL

*The above data is based on the productmolecular weight 450.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11500
MECHANISM OF ACTION Antagonist
M. Wt 450.92
Formula C23H23ClN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1030377-33-3
Synonyms MK4305, MK 4305
SMILES C[C@@H]1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl

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