Review date: Nov 28, 2018

1.      IDENTIFICATION OF THE PRODUCT AND OF THE COMPANY

1.1.      Product identifiers

Product Name:

Preladenant

Catalog No.:

A13504

CAS:

377727-87-2

1.2.      Relevant identified uses of the substance or mixture and uses advised against

Identified Uses:      Laboratory chemicals, Manufacture of substances

1.3.      Details of the supplier of the safety data sheet

Company:

Adooq Bioscience LLC

Telephone:

+1 866-930-6790

 

4000 Barranca Parkway, Suite 250

Fax:

+1 866-333-9607

 

Irvine, CA 92604

Website:

www.adooq.com

 

United States

Email:

info@adooq.com

1.4.      Emergency Telephone number

Emergency phone #: +1 866-930-6790

2.      HAZARDS IDENTIFICATION

2.1.      Classification of the substance or mixture

This substance does not meet the classification criteria of the EC Directives 67/548/EEC, 1999/45/EC or 1272/2008.

2.2.      Label elements

The product does not need to be labeled in accordance with EC directives or respective national laws.

2.3.      Other hazards

None.

3.      COMPOSITION/INFORMATION ON INGREDIENTS

3.1.      Substances

Product Name:

Preladenant

CAS:

377727-87-2

Formula:

C25H29N9O3

Molecular Weight:

503.56

Synonyms:

SCH 420814

4.      FIRST AID MEASURES

4.1.      Description of first aid measures

General advice

Consult a doctor and show this safety data sheet.

If inhaled

Remove to fresh air and monitor breathing. If breathing becomes difficult, give oxygen. If breathing stops, give artificial respiration. Consult a doctor.

In case of skin contact

Immediately wash skin with copious amounts of soap and water for at least 15 minutes. Remove contaminated clothing and shoes and wash before reuse. Consult a doctor.

In case of eye contact

Flush with copious amounts of water for at least 15 minutes. Consult a doctor.

If swallowed

Rinse mouth with water. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Consult a doctor.

4.2.      Most important symptoms and effects, both acute and delayed

To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly investigated.

4.3.      Indication of immediate medical attention and special treatment needed

Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.

5.      FIRE FIGHTING MEASURES

5.1.      Extinguishing media

Suitable extinguishing media

Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.

5.2.      Special hazards arising from the substance or mixture

During combustion, may emit irritant fumes.

5.3.      Advice for firefighters

Wear self-contained breathing apparatus and protective clothing.

6.      ACCIDENTIAL RELEASE MEASURES

6.1.      Personal precautions, protective equipment and emergency procedures

Do not take action without suitable protective clothing - see section 8 of SDS. Evacuate personnel to safe areas. Ensure adequate ventilation. Avoid breathing vapors, mist, dust or gas.

6.2.      Environmental precautions

Do not let product enter drains.

6.3.      Methods and materials for containment and cleaning up

Cover spillage with suitable absorbent material. Using non-spark tools, sweep up material and place in an appropriate container. Decontaminate spill site with 10% caustic solution and ventilate area until after disposal is complete. Hold all material for appropriate disposal as described under section 13 of SDS.

6.4.      Reference to other sections

For required PPE see section 8. For disposal see section 13.

 

7.      HANDLING AND STORAGE

7.1.      Precautions for safe handling

Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.

7.2.      Conditions for safe storage, including any incompatibilities.

Store in cool, well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use. Recommended storage temperature: Store at -20°C.

7.3.      Specific end uses

Use in a laboratory fume hood where possible. Refer to employer's COSHH risk assessment.

8.      EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1.      Control parameters

Components with workplace control parameters

Contains no substances with occupational exposure limit values.

8.2.      Exposure controls

Appropriate engineering controls

Use in a fume hood where applicable. Ensure all engineering measures described under section 7 of SDS are in place. Ensure laboratory is equipped with a safety shower and eye wash station.

Personal protective equipment

Eye/face protection

Use appropriate safety glasses.

Skin protection

Use appropriate chemical resistant gloves (minimum requirement use standard BS EN 374:2003). Gloves should be inspected before use. Wash and dry hands thoroughly after handling.

Body protection

Wear appropriate protective clothing.

Respiratory protection

If risk assessment indicates necessary, use a suitable respirator.

9.      PHYSICAL AND CHEMICAL PROPERTIES

9.1.      Information on basic physical and chemical properties

Appearance:

No data available

Vapor pressure:

No data available

Odor:

No data available

Vapor density:

No data available

Odor threshold:

No data available

Relative density:

No data available

pH:

No data available

Solubility(ies):

No data available

Melting / freezing point:

No data available

Partition coefficient:

No data available

Boiling point / range:

No data available

Auto-ignition temperature:

No data available

Flash point:

No data available

Decomposition temperature:

No data available

Evaporation rate:

No data available

Viscosity:

No data available

Flammability (solid, gas):

No data available

Explosive properties:

No data available

Upper / lower flammability or explosive limits:

No data available

Oxidising properties:

No data available

9.2.      Other safety information

No data available.

10.   STABILITY AND REACTIVITY

10.1.   Reactivity

Stable under recommended transport or storage conditions.

10.2.   Chemical stability

Stable under recommended storage conditions.

10.3.   Possibility of hazardous reactions

Hazardous reactions will not occur under normal transport or storage conditions. Decomposition may occur on exposure to conditions or materials listed below.

10.4.   Conditions to avoid

Heat, moisture.

10.5.   Incompatible materials

Strong acids/alkalis, strong oxidising/reducing agents.

10.6.   Hazardous decomposition products

In combustion may emit toxic fumes. No known decomposition information.

11.   TOXICOLOGICAL INFORMATION

11.1.   Information on toxicological effects

Acute toxicity

Classified based on available data. For more details, see section 2.

Skin corrosion/irritation

Classified based on available data. For more details, see section 2.

Serious eye damage/irritation

Classified based on available data. For more details, see section 2.

Respiratory or skin sensitization

Classified based on available data. For more details, see section 2.

Germ cell mutagenicity

Classified based on available data. For more details, see section 2.

Carcinogenicity

Classified based on available data. For more details, see section 2.

Reproductive toxicity

Classified based on available data. For more details, see section 2.

Specific target organ toxicity - single exposure

Classified based on available data. For more details, see section 2.

Specific target organ toxicity - repeated exposure

Classified based on available data. For more details, see section 2.

Aspiration hazard

Classified based on available data. For more details, see section 2.

Additional Information

RTECS No: not available

Exposure may cause irritation of eyes, mucous membranes, upper respiratory tract and skin.

To the best of our knowledge, the chemical, physical and toxicological properties have not been fully investigated.

12.   ECOLOGICAL INFORMATION

12.1.   Toxicity

No data available.

12.2.   Persistence and degradability

No data available.

12.3.   Bioaccumlative potential

No data available.

12.4.   Mobility in soil

No data available.

12.5.   Results of PBT and vPvB assessment

PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.

12.6.   Other adverse effects

No data available.

13.   DISPOSAL CONSIDERATIONS

13.1.   Waste treatment methods

Product

Dispose substance in accordance with prevailing country, federal, state and local regulations.

Contaminated packaging

Conduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.

14.   TRANSPORT INFORMATION

Classified according to the criteria of the UN Model Regulations as reflected in the IMDG Code, ADR, RID and IATA.

14.1.   UN-Number

Does not meet the criteria for classification as hazardous for transport.

14.2.   UN proper shipping name

Does not meet the criteria for classification as hazardous for transport.

14.3.   Transport hazard class(es)

Does not meet the criteria for classification as hazardous for transport.

14.4.   Packaging group

Does not meet the criteria for classification as hazardous for transport.

14.5.   Environmental hazards

This product is not classified as environmentally hazardous according to the UN Model Regulations, nor a marine pollutant according to the IMDG Code.

14.6.   Special precautions for users

No data available.

15.   REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.

15.1.   Safety, health and environmental regulations/legislation specific for the substance or mixture

TSCA (Toxic Substance Control Act)

No data available.

SARA 313 Components:

No data available.

SARA 311/312 Hazards:

No data available.

Massachusetts Right To Know Components:

No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know Components:

No components are subject to the Pennsylvania Right to Know Act.

New Jersey Right To Know Components:

No components are subject to the New Jersey Right to Know Act.

California Prop. 65 Components:

No data available.

15.2.   Chemical safety assessment

A Chemical Safety Assessment has not been made for this product.

16.   OTHER INFORMATION

The above information is believed to be correct but does not purport to be all inclusive and should be used as a guide only for experienced personnel. The product is for research use only and for trained personnel. Always consult your safety advisor and follow appropriate local and national safety legislature. ADOOQ BIOSCIENCE disclaims all liability for any damage resulting from use of this material. The burden of safe use of this material rests entirely with the user.

-End of safety data sheet-