“pb 22”的搜索结果

产品 1 到 50 共 3389个

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  1. Corticosterone

    Catalog No. A14269
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    Corticosterone 是一种具有口服活性的,由肾上腺皮质产生的糖皮质激素,在调节边缘系统 (包括海马体、前额叶皮层和杏仁核) 的神经元功能方面起着重要作用。皮质酮可通过 SGK 诱导的 GDI 磷酸化增加 Rab 介导的 AMPAR 膜运输. 了解更多
  2. Avelumab

    Catalog No. A18234
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    PD-1/PD-L1
    Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity. 了解更多
  3. Exendin-4

    Catalog No. A21580
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    glucagon-like peptide-1 receptor agonist
    Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. 了解更多
  4. BI-4020

    Catalog No. A22046
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    EGFR inhibitor
    BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFR. 了解更多
  5. SR-717

    Catalog No. A22048
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    non-nucleotide STING agonist
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. 了解更多
  6. Apilimod mesylate

    Catalog No. A22049
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    IL-12/IL-23 inhibitor
    Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. 了解更多
  7. DT2216

    Catalog No. A22050
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    BCL-XL degrader
    DT2216 is a potent and selective BCL-XL degrader based on PROTAC technology. 了解更多
  8. Sulopenem

    Catalog No. A22051
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    beta-lactamase inhibitor
    Sulopenem (CP-70429) is an orally active, potent inhibitor of beta-lactamase. Sulopenem is a parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. 了解更多
  9. BMVC-8C3O

    Catalog No. A22052
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    DNA G-quadruplexe (G4) ligand
    BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. 了解更多
  10. XP-59

    Catalog No. A22053
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    SARS-CoV Mpro inhibitor
    XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM. 了解更多
  11. LC3-mHTT-IN-AN1

    Catalog No. A22054
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    mHTT-LC3 linker compound
    LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. 了解更多
  12. APX-115 free base

    Catalog No. A22055
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    pan NADPH oxidase (Nox) inhibitor
    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. 了解更多
  13. Mizagliflozin

    Catalog No. A22056
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    SGLT1 inhibitor
    Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. 了解更多
  14. TLR4-IN-C34

    Catalog No. A22057
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    TLR4 inhibitor
    TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis. 了解更多
  15. DIMBOA

    Catalog No. A22058
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    antifungal agent
    Dimboa is an antifungal agent used in crops. 了解更多
  16. H-β-Ala-AMC TFA

    Catalog No. A22059
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    substrate for aminopeptidase
    H-β-Ala-AMC TFA is a substrate for aminopeptidase. 了解更多
  17. PF-04745637

    Catalog No. A22060
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    TRPV1 antagonist
    PF-04745637 is a TRPV1 antagonist. 了解更多
  18. BMS-1001

    Catalog No. A22061
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    PD-1/PD-L1 interaction inhibitor
    BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. 了解更多
  19. KGA-2727

    Catalog No. A22062
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    SGLT1 inhibitor
    KGA-2727 is a first selective, high-affinity and orally active SGLT1 inhibitor with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. 了解更多
  20. Filastatin

    Catalog No. A22063
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    Candida albicans filamentation inhibitor
    Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. 了解更多
  21. Neuraminidase-IN-1

    Catalog No. A22065
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    neuraminidase inhibitor
    Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC50 of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus. 了解更多
  22. 9-ING-41

    Catalog No. A22066
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    glycogen synthase kinase-3β (GSK-3β) inhibitor
    9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 了解更多
  23. BAY 2416964

    Catalog No. A22067
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    aryl hydrocarbon receptor (AHR) antagonist
    BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment. 了解更多
  24. GSK046

    Catalog No. A22068
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    BD2 bromodomain inhibitor of the BET proteins
    GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. 了解更多
  25. DiZPK

    Catalog No. A22069
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    photocrosslinker
    DiZPK is a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells. 了解更多
  26. CWP232228

    Catalog No. A22070
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    Wnt/β-catenin signaling inhibitor
    CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. 了解更多
  27. HS-243

    Catalog No. A22071
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    transforming growth factor-?beta kinase inhibitor
    HS-243 is an inhibitor of transforming growth factor-?beta kinase. HS-243 can be used in treatment of cancer, malaria, inflammatory and other TAK1-?mediated diseases. 了解更多
  28. CYM50308

    Catalog No. A22072
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    sphingosine-1-phosphate receptor 4 (S1P4-R) agonist
    CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. 了解更多
  29. Fluxapyroxad

    Catalog No. A22073
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    the succinate dehydrogenase (SQR) enzyme inhibitor
    Fluxapyroxad, a broad-spectrum fungicide, is an inhibitor of the succinate dehydrogenase (SQR) enzyme. 了解更多
  30. PF9601N

    Catalog No. A22075
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    monoamine oxidase B inhibitor
    PF9601N is a selective and potent monoamine oxidase B inhibitor that exhibit anti-Parkinsonian effects in several models of PD. 了解更多
  31. CRANAD-2

    Catalog No. A22076
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    near-infrared (NIR) probe
    CRANAD-2 is a curcumin-derivatized near-infrared (NIR) probe that meets all the requirements for a NIR contrast agent for the detection of Abeta plaques both in vitro and in vivo. 了解更多
  32. DGY-06-116

    Catalog No. A22077
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    Src inhibitor
    DGY-06-116 is an irreversible covalent, selective Src inhibitor. 了解更多
  33. HA155

    Catalog No. A22079
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    Autotaxin Inhibitor IV
    HA155, also known as Autotaxin Inhibitor IV, is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine. 了解更多
  34. ASN03576800

    Catalog No. A22080
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    ASN03576800 is an inhibitor of the VP40 matrix protein. 了解更多
  35. YMU1

    Catalog No. A22081
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    human thymidylate kinase (hTMPK) inhibitor
    YMU1 is an inhibitor of human thymidylate kinase (hTMPK). 了解更多
  36. BMS453

    Catalog No. A22082
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    RARβ agonist
    BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. 了解更多
  37. GW779439X

    Catalog No. A22083
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    cyclin dependent kinase inhibitor
    GW779439X is an inhibitor of cyclin dependent kinase. 了解更多
  38. 4BP-TQS

    Catalog No. A22084
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    neuronal nicotinic acetylcholine receptors agonist
    4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs). 了解更多
  39. RO2959 hydrochloride

    Catalog No. A22085
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    CRAC channel inhibitor
    RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. 了解更多
  40. B355252

    Catalog No. A22086
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    neuroprotective agent
    B355252 is a neuroprotective agent potentiating nerve growth factor (NGF)-induced neurite outgrowth. 了解更多
  41. GW280264X

    Catalog No. A22087
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    ADAM17 inhibitor
    GW280264X is an ADAM17 inhibitor. 了解更多
  42. ML191

    Catalog No. A22088
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    GPR55 antagonist
    ML191 (CCG-152883, CID-23612552) is an antagonist of GPR55 with EC50 of 1.076 ?M in U2OS cells overexpressing GPR55. 了解更多
  43. ML298

    Catalog No. A22089
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    Phospholipase D2 (PLD2) inhibitor
    ML298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2) with IC50 of 355 nM. 了解更多
  44. G244-LM

    Catalog No. A22090
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    tankyrase 1/2 inhibitor
    G244-LM is a potent and specific tankyrase 1/2 inhibitor that inhibits Wnt signaling. 了解更多
  45. YM26734

    Catalog No. A22091
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    rabbit platelet sPLA2 inhibitor
    YM-26734 is a rabbit platelet sPLA2 inhibitor that has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema. 了解更多
  46. CYM 2503

    Catalog No. A22092
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    positive allosteric modulator (PAM)
    CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. 了解更多
  47. API-1

    Catalog No. A22093
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    Akt inhibitor
    API-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. 了解更多
  48. ML299

    Catalog No. A22094
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    PLD1/PLD2 dual inhibitor
    ML299 (VU0463568) is a dual inhibitor of PLD1 and PLD2 with IC50 of 6 nM and 20 nM, respectively. 了解更多
  49. SW155246

    Catalog No. A22095
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    DNMT1 inhibitor
    SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells. 了解更多
  50. Apcin

    Catalog No. A22096
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    E3 ligase activity inhibitor
    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. 了解更多

产品 1 到 50 共 3389个

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