微信关注
Total item
Cart Subtotal
￥ 0.00 PI3K
| Catalog No. | Inhibitor Name | PI3K | p110α | p110β | p110δ | p110γ | C2α | C2β | Vps34 | Other Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| A10133 | Dactolisib (BEZ235, NVP-BEZ235) | **** | ** | *** | *** | mTOR (p70S6K),ATR | ||||
| A10421 | Pictilisib (GDC-0941) | **** | ** | **** | ** | * | mTOR | |||
| A10547 | LY294002 | * | * | * | ||||||
| A10172 | Idelalisib (CAL-101, GS-1101) | * | * | **** | ** | * | DNA-PK | |||
| A11016 | Buparlisib (BKM120, NVP-BKM120) | ** | * | ** | * | * | mTOR | |||
| A10726 | PI-103 | **** | **** | **** | *** | DNA-PK,mTOR | ||||
| A10923 | TGX-221 | * | **** | ** | ||||||
| A10463 | IC-87114 | * | ** | * | ||||||
| A11161 | Wortmannin | **** | DNA-PK,ATM,MLCK | |||||||
| A10995 | XL147 analogue | *** | ** | *** | *** | |||||
| A11014 | ZSTK474 | *** | *** | *** | **** | ** | ||||
| A11328 | Alpelisib (BYL719) | **** | ||||||||
| A10088 | AS-605240 | ** | * | * | *** | |||||
| A10729 | PIK-75 HCl | *** | * | ** | DNA-PK | |||||
| A11151 | 3-Methyladenine (3-MA) | * | * | |||||||
| A11202 | A66 | *** | * | * | PI4Kβ | |||||
| A10731 | PIK-93 | *** | * | ** | *** | * | ** | * | PI4KIIIβ,DNA-PK,ATM | |
| A11035 | Omipalisib (GSK2126458, GSK458) | **** | **** | **** | **** | mTORC1,mTORC2 | ||||
| A10730 | PIK-90 | *** | * | ** | *** | |||||
| A11024 | PF-04691502 | **** | **** | **** | **** | P-Akt (S473),P-Akt (T308),mTOR | ||||
| A10112 | AZD6482 | * | *** | ** | * | DNA-PK | ||||
| A11023 | Apitolisib (GDC-0980, RG7422) | **** | *** | *** | *** | mTOR | ||||
| A10438 | GSK1059615 | **** | **** | **** | **** | mTOR | ||||
| A12422 | Duvelisib (IPI-145, INK1197) | *** | **** | **** | **** | |||||
| A11079 | Gedatolisib (PF-05212384, PKI-587) | **** | **** | mTOR | ||||||
| A10922 | TG100-115 | * | * | ** | ** | |||||
| A11099 | AS-252424 | * | *** | Casein Kinase 2 | ||||||
| A11162 | BGT226 (NVP-BGT226) | **** | ** | *** | mTOR | |||||
| A11153 | CUDC-907 | *** | ** | *** | * | HDAC1,HDAC3,HDAC10 | ||||
| A10728 | PIK-294 | * | *** | ** | ||||||
| A11197 | AS-604850 | * | ** | |||||||
| A11766 | Copanlisib (BAY 80-6946) | **** | **** | **** | *** | |||||
| A11064 | YM201636 | * | PIKfyve | |||||||
| A11169 | CH5132799 | *** | ** | * | *** | |||||
| A10727 | PIK-293 | * | * | ** | * | |||||
| A11089 | PKI-402 | **** | *** | *** | *** | mTOR | ||||
| A11956 | TG100713 | ** | ** | *** | ** | |||||
| A12480 | VS-5584 (SB2343) | **** | *** | **** | **** | mTOR | ||||
| A12831 | Taselisib (GDC 0032) | **** | *** | **** | **** | * | * | |||
| A11363 | CZC24832 | * | * | *** | ||||||
| A16332 | IPI-549 | * | * | * | *** | |||||
| A16277 | TGR-1202 | *** | ||||||||
| A16272 | GDC-0084 | **** | ** | **** | *** | mTOR | ||||
| A16352 | AZD8835 | *** | * | **** | ** | |||||
| A15868 | PIK-III | * | * | * | *** | |||||
| A15874 | VPS34-IN1 | *** | ||||||||
| A16276 | Voxtalisib (XL765, SAR245409) | *** | ** | ** | *** | DNA-PK,mTOR | ||||
| A15901 | AMG319 | * | * | *** | * | |||||
| A15759 | AZD8186 | *** | **** | *** | * | |||||
| A12889 | PF-4989216 | **** | ** | **** | ** | |||||
| A15283 | Pilaralisib (XL147) | ** | *** | *** | *** | |||||
| A14338 | PI-3065 | * | * | *** | * | |||||
| A13021 | HS-173 | **** | ||||||||
| A10766 | Quercetin | * | * | * | PKC,Src,Sirtuin | |||||
| A11784 | GSK2636771 | |||||||||
| A11196 | CAY10505 | |||||||||
| A16126 | LY3023414 | DNA-PK,mTOR kinase | ||||||||
| A13992 | GNE-317 | |||||||||
| A14441 | Acalisib (GS-9820) | |||||||||
| A16273 | NVP-QAV-572 | |||||||||
| A16266 | ON 146040 | *** | *** | |||||||
| A15992 | PQR309 | |||||||||
| A15529 | MLN1117 (Serabelisib) | *** | ||||||||
| A15030 | CAL-130 | |||||||||
| A14379 | Panulisib (P7170, AK151761) | ALK1, mTOR, DNA-PK | ||||||||
| A13879 | CNX-1351 | **** | ||||||||
| A11198 | D-106669 | **** | ||||||||
| A11261 | PX-866 (Sonolisib) | **** | * | **** | *** | |||||
| A11511 | NVP-BAG956 | *** | * | *** | ** | PDK1 | ||||
| A12935 | PF-04979064 | **** | **** | **** | **** | mTOR | ||||
| A13328 | ETP-46464 | * | mTOR, DNA-PK, ATR, ATM | |||||||
| A14432 | GNE-493 | **** | *** | *** | *** | mTOR |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
-
Seletalisib (UCB-5857)
Catalog No. A16797 PI3K 抑制剂Seletalisib (UCB-5857)是一种新型的PI3Kδ小分子抑制剂，其IC50值为12 nM，相对于其他I类PI3K亚型（介于24-303倍之间），对PI3Kδ具有显著的选择性。 了解更多 -
leniolisib (CDZ 173)
Catalog No. A16796 PI3K 抑制剂Leniolisib (CDZ 173)是一种有效的、选择性的PI3Kδ抑制剂，对PI3Kα、PI3Kβ、PI3Kγ和PI3Kδ的生化IC50值分别为0.244、0.424、2.23和0.011 uM。 了解更多 -
Vps34-IN-2
Catalog No. A16933 Vps34 抑制剂Vps34-IN-2是一种新颖，有效和选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50分别为2和82 nM。 了解更多 -
SAR260301
Catalog No. A16877 -
Pictilisib dimethanesulfonate
Catalog No. A11444 PI3Kα/δ inhibitorPictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). 了解更多 -
Dactolisib Tosylate
Catalog No. A11327 dual PI3K and mTOR kinase inhibitorDactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2. 了解更多 -
Parsaclisib
Catalog No. A13561 PI3Kδ inhibitorParsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. 了解更多 -
CAL-130 Racemate
Catalog No. A20942 PI3Kδ inhibitorCAL-130 Racemate is the racemate of CAL-130. CAL-130 Racemate is a PI3Kδ inhibitor. 了解更多 -
Alpelisib hydrochloride
Catalog No. A21794 PI3Kα inhibitorAlpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. 了解更多 -
Umbralisib R-enantiomer
Catalog No. A21993 PI3Kδ inhibitorUmbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202. 了解更多 -
GSK2292767
Catalog No. A16564 PI3Kδ inhibitorGSK2292767 is a potent and selective inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ; Ki = 79 pM). GSK2292767 is >100-fold selective for PI3Kδ over a panel of 250 kinases. 了解更多 -
PI3Kdelta inhibitor 1
Catalog No. A19249 PI3Kδ inhibitorPI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM. 了解更多 -
CHMFL-PI3KD-317
Catalog No. A19990 PI3Kδ inhibitorCHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM. 了解更多