PARP

Inhibitory Selectivity

Catalog No.	Inhibitor Name	PARP	PARP1	PARP2	PARP3	V-PARP	Tankyrase-1
A10111	Olaparib		***	****			*
A10026	Veliparib		***	***
A14182	Rucaparib	****
A11243	Talazoparib	****
A10046	AG-14361		***
A10475	INO-1001	**
A10019	A-966492		****	****
A15215	PJ34	***
A12665	PJ34 HCl	***
A11026	Niraparib		***	****	*	**	**
A12750	UPF 1069		*	**
A14309	ME0328		*		**
A14371	Benzamide	*
A15375	NU1025	**
A10164	Iniparib
A12393	AZD2461
A16344	BGP-15
A10045	AG-014699 (Rucaparib)	****
A15370	4-HQN	*
A15371	BYK 204165		*	*
A15372	BYK 49187		*	*
A15374	EB 47		**
A15373	DR 2313		*	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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EB 47

Catalog No. A15374
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PARP1 抑制剂

EB 47是PARP1的有效抑制剂，IC50为45 nM。了解更多

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BYK 49187

Catalog No. A15372
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PARP-1/PARP-2 抑制剂

BYK 49187，PARP-1和PARP-2抑制剂（无细胞重组PARP-1和鼠PARP-2的pIC50值分别为8.36和7.50）。了解更多

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DR 2313

Catalog No. A15373
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PARP 抑制剂

DR 2313是一种水溶性嘧啶酮化合物，起PARP（聚（ADP-核糖）聚合酶）抑制剂的作用。了解更多

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BYK 204165

Catalog No. A15371
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PARP-1 抑制剂

BYK204165是一种可渗透细胞的异喹啉二酮化合物，可有效并选择性地抑制聚（ADP-核糖）聚合酶1（PARP1）。了解更多

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Rucaparib

Catalog No. A14182
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PARP-1 抑制剂

Rucaparib是纯化的全长人PARP-1的有效抑制剂，对LoVo和SW620细胞中的细胞PARP具有更高的抑制作用。了解更多

Product Citations (1)

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- Jianwei Dou, .et al. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography, J Sep Sci, 2020, Dec 4 PMID: 33275824
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MK-4827 (Niraparib)

Catalog No. A11026
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PARP 抑制剂

MK-4827 (Niraparib)是一种新型有效的口服生物可利用的PARP-1和PARP-2抑制剂。了解更多

Product Citations (5)

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- Joseph M Gozgit, .et al. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity, Cancer cell, 2021, Jul 22;S1535-6108(21)00340-8 PMID: 34375612
- Ann-Katrin Hopp, .et al. Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation, Molecular cell, 2021, Jan 21; 81(2): 340?C354 PMID: 33450210
- Bian C, .et al. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression, Nat Commun, 2019, Feb 11;10(1):693 PMID: 30741937
- Tahira Baloch, .et al. Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1, BMC Cancer, 2019, Jan 10;19(1):44 PMID: 30630446
- Khalid Hilmi, .et al. CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair, Sci Adv, 2017, May; 3(5): e1601898 PMID: 28560323
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BSI-201 (Iniparib)

Catalog No. A10164
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PARP 抑制剂

BSI-201 (Iniparib)是一种有效的PARP-1抑制剂，已被证明可以穿越血脑屏障。了解更多

Product Citations (1)

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- Jianwei Dou, .et al. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography, J Sep Sci, 2020, Dec 4 PMID: 33275824
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Benzamide

Catalog No. A14371
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PARP-1 抑制剂

Benzamide是苯甲酸的酰胺衍生物，是聚（ADP-核糖）聚合酶-1（PARP-1）的抑制剂。了解更多

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UPF 1069

Catalog No. A12750
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PARP2 抑制剂

UPF 1069是一种选择性聚（ADP-核糖）聚合酶（PARP）2抑制剂（PARP-2和PARP-1的IC50值分别为0.3和8.0μM）。了解更多

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A-966492

Catalog No. A10019
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PARP1 抑制剂

A-966492在全细胞试验中显示出对K（i）为1 nM，EC（50）为1 nM的聚（ADP-核糖）聚合酶-1（PARP-1）酶的高效力。了解更多

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