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VX-809 (Lumacaftor)

Catalog No. A10986
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CFTR modulator

VX-809 (Lumacaftor)是用于治疗囊性纤维化（CF）的第二种口服研究候选化合物，通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正囊性纤维症中常见的CFTR突变，在fisher大鼠甲状腺细胞中EC50为0.1 μM。了解更多

Product Citations (4)

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- Kusumika Saha, .et al. Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites, Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
- Heledd H Jarosz-Griffiths, .et al. Different CFTR Modulator Combinations Downregulate Inflammation Differently in Cystic Fibrosis, Elife, 2020, Mar 2;9:e54556 PMID: 32118580
- Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
- Junko Kido, .et al. Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion, Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
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Indiplon

Catalog No. A13769
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GABAA receptor modulator

Indiplon是吡唑并嘧啶，可作为GABAA受体的高亲和力正变构调节剂，以剂量依赖和可逆的方式增强GABA活化的氯离子电流。了解更多

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BINA

Catalog No. A11126
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mGluR2 modulator

BINA是mGlu2的选择性正构构调节剂（在表达人mGlu2的CHO细胞中EC50 = 33.2 nM）。了解更多

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Lorediplon

Catalog No. A13449
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GABAA receptor modulator

Lorediplon 是一种新型的非苯二氮卓类催眠药，作为GABAA受体调节剂。了解更多

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LY335979 (Zosuquidar 3HCl)

Catalog No. A10549
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P-gp modulator

LY335979 (Zosuquidar trihydrochloride)是一种强效高选择性P-gp抑制剂。了解更多

Product Citations (1)

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- Leo Shen, .et al. A forward genetic screen identifies modifiers of rocaglate responsiveness, Sci Rep, 2021, Sep 16;11(1):18516 PMID: 34531456
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GLYX-13 (Rapastinel)

Catalog No. A13576
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NMDAR modulator

GLYX-13 (Rapastinel)是NMDA受体甘氨酸位点的选择性弱部分激动剂。了解更多

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Ostarine (MK-2866, GTx-024)

Catalog No. A10253
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Androgen Receptor Modulators

Ostarine (MK-2866,GTX-024)是一种雄激素受体调节剂(SARM)。了解更多

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Rostafuroxin (PST-2238)

Catalog No. A13283
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Na+/K+ ATPase modulator

Rostafuroxin (PST-2238)是一种哇巴因抑制剂，可对抗特定形式的高血压。了解更多

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VU 0364770

Catalog No. A12139
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mGlu4 receptors modulator

VU 0364770是mGlu4受体的正变构调节剂，在表达mGlu4的HEK 293细胞中EC50值为290 nM。了解更多

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PNU-120596

Catalog No. A11203
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Nicotinic (α7) Receptor Modulator

PNU-120596是α7神经元烟碱型乙酰胆碱受体的正变构调节剂。了解更多

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GSK-2881078

Catalog No. A12645
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androgen receptor modulator

GSK-2881078是一种选择性雄激素受体调节剂（SARM），正在针对肌肉萎缩以改善其身体功能的受试者的肌肉生长和力量进行评估。了解更多

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