S1P Receptor

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  1. ASP1126

    Catalog No. A18432
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    S1P agonist
    ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. 了解更多
  2. Fingolimod

    Catalog No. A17798
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    S1P antagonist
    Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. 了解更多
  3. KRP-203

    Catalog No. A13308
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    S1PR1 抑制剂
    KRP-203是选择性鞘氨醇-1-磷酸受体激动剂。它表明减少大鼠移植模型中外周淋巴细胞的浸润并延长生存期。 了解更多
  4. SKI-II

    Catalog No. A15988
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    SphK 抑制剂
    SKI-II是鞘氨醇激酶的选择性非脂质抑制剂(IC50 = 0.5 uM)。 了解更多
  5. Ponesimod

    Catalog No. A13307
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    S1P1 receptor modulator
    Ponesimod是一种口服活性,选择性鞘氨醇-1-磷酸受体1(S1P1)免疫调节剂,EC50为5.7 nM。 了解更多
  6. NS13001

    Catalog No. A15833
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    SK2 modulator
    NS13001是选择性的SK2/3调节剂,可作为治疗SCA2和其他可能的小脑共济失调的潜在治疗剂。 了解更多
  7. RPC1063 (Ozanimod)

    Catalog No. A15819
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    S1PR1 modulators
    RPC1063 (Ozanimod)是选择性的鞘氨醇1磷酸酯受体调节剂和方法,可用于治疗与S1P1-β相关的疾病。 了解更多
  8. PF-543 Citrate

    Catalog No. A15210
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    SphK1 抑制剂
    PF-543 Citrate是一种新型的SphK1细胞渗透抑制剂,K(i)为3.6 nM,PF-543具有鞘氨醇竞争性,对SphK1的选择性是SphK2同种型的100倍以上。 了解更多
  9. CYM 5442 HCl

    Catalog No. A13637
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    EDG-1 (S1P1) 激动剂
    CYM 5442 HCl是一种有效的体外选择性EDG-1(S1P1)激动剂(EC50 = 1.35 nM)。 了解更多
  10. ABC294640

    Catalog No. A12614
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    SphK2 抑制剂
    ABC294640是一种口服的芳基金刚烷化合物,是鞘氨醇激酶2(SK2)的选择性抑制剂,Ki 为 9.8 μM,具有潜在的抗肿瘤活性。 了解更多
  11. PF-543

    Catalog No. A13039
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    SphK1 抑制剂
    PF-543是一种新型选择性SK-1抑制剂,可与鞘氨醇竞争性抑制SK-1活性。 了解更多
  12. BAF312 (Siponimod)

    Catalog No. A12906
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    S1PR1/S1PR5 抑制剂
    BAF312 (Siponimod)是下一代有效的1-磷酸鞘氨醇(S1P)受体激动剂,对S1P1和S1P5具有选择性。 了解更多
  13. FTY720 (Fingolimod)

    Catalog No. A10408
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    S1P Receptor 拮抗剂
    FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物,ISP-1是中国草药Iscaria sinclarii的真菌代谢物,也是鞘氨醇的结构类似物。 了解更多
  14. PF429242 dihydrochloride

    Catalog No. A21386
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    S1P inhibitor
    PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. 了解更多
  15. FTY720 (S)-Phosphate

    Catalog No. A21324
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    S1PR1 agonist
    FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. 了解更多
  16. Cenerimod

    Catalog No. A20913
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    S1P1 agonist
    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. 了解更多
  17. TY-52156

    Catalog No. A12265
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    S1P3 receptor antagonist
    TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM. 了解更多
  18. VPC 23019

    Catalog No. A20102
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    S1P antagonist
    VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). 了解更多
  19. MP-A08

    Catalog No. A16290
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    ATP competitive SK 抑制剂
    MP-A08是一种高度选择性的ATP竞争性SK抑制剂,其靶向SK1和SK2的Kivalue分别为6.9±0.8 uM和27±3 uM。 了解更多
  20. K145 hydrochloride

    Catalog No. A16289
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    SphK2 抑制剂
    K145 hydrochloride是选择性鞘氨醇激酶2(SphK2)抑制剂和抗癌剂。 了解更多
  21. K145

    Catalog No. A16288
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    SphK2 抑制剂
    K145是一种选择性SphK2抑制剂,IC50为4.30±0.06μM,而在浓度不超过10 uM时,对SphK1无抑制作用。 了解更多

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