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使用 'CDK2' 作为标签的产品

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AZD5438

Catalog No. A11105
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CDK 抑制剂

AZD5438是有效的细胞周期蛋白依赖性激酶（CDK）1、2和9抑制剂（IC50值分别为16、6和20 nM）。了解更多

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BMS-265246

Catalog No. A11154
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CDK 抑制剂

BMS-265246是cdk2/cyclin E和cdk1/cyclin B以及cdk4/cyclin D的强新吡唑并吡啶抑制剂。了解更多

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Dinaciclib (SCH 727965)

Catalog No. A11129
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CDK 抑制剂

Dinaciclib (SCH 727965)是一种有效且选择性的细胞周期蛋白依赖性激酶（CDK）抑制剂，选择性抑制CDK1，CDK2，CDK5和CDK9，IC50值分别为3、1、1和4 nM。了解更多

Product Citations (3)

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- Sepideh Izadi, .et al. Codelivery of HIF-1α siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression, Pharm Res, 2020, Sep 17;37(10):196 PMID: 32944844
- Shahin Hallaj, .et al. Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib, Life Sci, 2020, Jul 26 PMID: 32726663
- Washio I, .et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888
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Flavopiridol (Alvocidib)

Catalog No. A10390
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CDK 抑制剂

Flavopiridol（Alvocidib）是一种细胞周期蛋白依赖性激酶抑制剂，与ATP竞争性抑制CDK，包括CDK1， CDK2， CDK4和CDK6，CDK9。作用于CDK1， 2， 4， 6，9比作用于CDK7更具有选择性，用于治疗慢性淋巴细胞性白血病。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Zhiyuan Zhao, .et al. CDK9 and SPT5 proteins are specifically required for expression of herpes simplex virus 1 replication-dependent late genes, J Biol Chem, 2017, Sep 15; 292(37): 15489-15500 PMID: 28743741
- Sami Kukkonen, .et al. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells, Retrovirology., 2014, 11: 30. PMID: 24742347
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Flavopiridol HCl

Catalog No. A11045
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CDK 抑制剂

Flavopiridol HCl是细胞周期蛋白依赖性激酶的抑制剂。（-）-顺式形式诱导特定肿瘤细胞的凋亡。了解更多

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GW 441756

Catalog No. A16238
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TrkA 抑制剂

GW 441756是一种特异的肌球蛋白相关激酶A（TrkA）抑制剂，IC50值为2 nM。对c-Raf1和CDK2几乎没有活性。了解更多

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K03861

Catalog No. A15889
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CDK 抑制剂

K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。了解更多

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NU6027

Catalog No. A14136
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ATR/CDK 抑制剂

NU6027是一种有效的细胞ATR活性抑制剂（IC（50）=6.7μM），并以ATR依赖的方式增强羟基脲和顺铂的细胞毒性。了解更多

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Purvalanol A

Catalog No. A15517
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CDK 抑制剂

Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。了解更多

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SCH 900776 (MK-8776)

Catalog No. A11167
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Chk1 抑制剂

SCH 900776 (MK-8776)是靶向细胞周期检查点激酶1（Chk1）的药物，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。了解更多

Product Citations (5)

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- Hong Yang, .et al. APOBEC3B Improves Response to PD-1 Blockade Through DSBs-ATR-CHK1 Pathway, Research Square, 2022, May 9th
- Motofumi Suzuki, .et al. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer, Int J Radiat Oncol Biol Phys, 2021, May 25;S0360-3016(21)00361-8 PMID: 34112559
- Min Wu, .et al. FLT3/ITD Cooperates With Rac1 To Modulate The Sensitivity Of Leukemic Cells To Chemotherapeutic Agents Via Regulation Of DNA Repair Pathways, Haematologica, 2019, 104 PMID: 30975911
- Permata TBM, .et al. Base excision repair regulates PD-L1 expression in cancer cells, Oncogene, 2019, Feb 12 PMID: 30755733
- Hiro Sato, .et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells, Nat Commun, 2017, 8: 1751 PMID: 29170499

Adooq Bioscience

使用 'CDK2' 作为标签的产品

AZD5438

BMS-265246

Dinaciclib (SCH 727965)

Flavopiridol (Alvocidib)

Flavopiridol HCl

GW 441756

K03861

NU6027

Purvalanol A

SCH 900776 (MK-8776)

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