使用 'DNA synthesis' 作为标签的产品
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Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂，结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能，使其与用作抗增殖剂的其他化合物区分开来，这些功能被认为可通过多种不同途径（包括凋亡和有丝分裂灾难）促进细胞死亡。
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Carboplatin是一种化学疗法药物，可用于治疗某些形式的癌症（主要是卵巢癌，肺癌，头颈癌）。顺铂和卡铂以及奥沙利铂与DNA相互作用，类似于烷基化剂的作用机理。
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- Jianwei Dou, .et al. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography, J Sep Sci, 2020, Dec 4 PMID: 33275824
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Topoisomerase 抑制剂
Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程，该酶使DNA中的超螺旋松弛以进行转录。
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Cisplatin是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。建议使用DMF溶解，而不是DMSO。
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- RUI-NING LIANG, .et al. Kidney mesenchymal stem cells alleviate cisplatin-induced kidney injury and apoptosis in rats, Research Square, 2022, July 6th
- Wei Zeng, .et al. Lidocaine suppresses the malignant behavior of gastric cancer cells via the c-Met/c-Src pathway, Exp Ther Med, 2021, May; 21(5): 424 PMID: 33747163
- Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492
- Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
- Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408
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Cytarabine通过掺入DNA抑制DNA复制（L1210和CEM细胞系中IC50 = 0.04μM）。
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DNA/RNA Synthesis 抑制剂
Daptomycin是一种脂肽抗生素，用于治疗由革兰氏阳性生物体引起的某些感染。
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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Shigeru Fujimura, .et al. Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices., J Infect Chemother., 2015, Oct;21(10):756-9 PMID: 26162777
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DNA/RNA Synthesis 抑制剂
Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，通过在癌细胞dna复制过程中取代核酸的一个组成部分，防止肿瘤生长。
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- G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
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DNA synthesis 抑制剂
Mitomycin C是一种DNA交联剂，可抑制DNA合成并诱导多种细胞凋亡。
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Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。
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DNA/RNA Synthesis 抑制剂
Oxaliplatin (Eloxatin)是一种DNA/RNA Synthesis抑制剂，具有抗结肠癌的抗肿瘤活性。
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- Mohamed Elbadawy, .et al. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids, Biomed Pharmacother, 2021, Oct;142:112043 PMID: 34411919
- Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
- Shimokawa M, .et al. Visualization and targeting of LGR5+ human colon cancer stem cells, Nature, 2017, May 11;545(7653):187-192 PMID: 28355176
- Eri Takiguchi, .et al. Growth inhibitory effect of the Src inhibitor dasatinib in combination with anticancer agents on uterine cervical adenocarcinoma cells, Exp Ther Med, 2017, Nov; 14(5): 4293-4299 PMID: 29067110
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Trifluridine 是一种抗疱疹病毒抗病毒药，主要用于眼睛。
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