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使用 'GSK-3β' 作为标签的产品

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1-Azakenpaullone

Catalog No. A14303
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GSK-3β 抑制剂

1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。了解更多

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AR-A 014418

Catalog No. A13728
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GSK-3 抑制剂

AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。了解更多

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- Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283
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AZD1080

Catalog No. A12819
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GSK3 抑制剂

AZD1080是一种新型GSK3抑制剂，可消除啮齿动物大脑中的突触可塑性缺陷，并在人类中表现出外周靶标参与。了解更多

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- Shengzhong Liu, .et al. STAT1-avtiviated LINC00961 regulates myocardial infarction by the PI3K/AKT/GSK3?? signaling pathway, J Cell Biochem, 2019, 2019
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BIO-acetoxime

Catalog No. A15555
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GSK-3 抑制剂

BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。了解更多

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CHIR-99021

Catalog No. A10199
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GSK-3 抑制剂

CHIR99021是一种GSK-3α和GSK-3β抑制剂，IC50值分别为10和6.7 nM。了解更多

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- Adam Pietrobon, .et al. Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes, Cell Rep, 2022, Jul 5;40(1):111048 PMID: 35793620
- Takayuki Miyoshi, .et al. Successful induction of human chemically induced liver progenitors with small molecules from damaged liver, J Gastroenterol, 2022, Jun;57(6):441-452 PMID: 35294680
- Tomoki Kamatani, .et al. Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model, Inflamm Regen, 2022, Feb 2;42(1):4 PMID: 35105370
- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Otsuka R, .et al. Efficient generation of thymic epithelium from induced pluripotent stem cells that prolongs allograft survival, Sci Rep, 2020, Jan 14;10(1):224 PMID: 31937817
- Yu Huang, .et al. Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors, Stem Cells Int, 2019, 2019: 3975689 PMID: 31565060
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IM-12

Catalog No. A14196
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GSK-3β 抑制剂

IM-12是一种细胞渗透性吲哚标记，作为糖原合成酶激酶3β（GSK-3β）抑制剂，激活典型Wnt信号的下游成分。了解更多

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LY2090314

Catalog No. A12741
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GSK-3 抑制剂

LY2090314是糖原合酶激酶3（GSK-3）的有效抑制剂，在许多途径中起重要作用，包括蛋白质合成的起始，细胞增殖，细胞分化和凋亡。了解更多

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- Yuki Shimizu, .et al. GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer, NPJ Precis Oncol, 2022, Mar 17;6(1):16 PMID: 35301419
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SB 216763

Catalog No. A10825
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GSK-3 抑制剂

SB 216763是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为34 nM（与GSK3β相似的效力）。了解更多

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SB 415286

Catalog No. A11061
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GSK-3 抑制剂

SB 415286是一种有效且具有选择性的细胞渗透性ATP竞争性GSK3α抑制剂，IC50值为78 nM（与GSK3β相似的效价），Ki值为31 nM。了解更多

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TDZD-8

Catalog No. A11941
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GSK-3 抑制剂

TDZD-8是一种非ATP竞争性GSK-3β抑制剂，IC50为2 μM；对CDK1， casein kinase II， PKA和PKC具有最低限度的抑制效果。了解更多

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Tideglusib

Catalog No. A11592
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GSK-3 抑制剂

Tideglusib是一种不可逆的，非ATP竞争性的GSK-3β抑制剂，无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。了解更多

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TWS119

Catalog No. A11223
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GSK-3 抑制剂

TWS119是4,6双取代的吡咯并嘧啶，可有效抑制GSK3β，IC50值为30 nM。了解更多

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Adooq Bioscience

使用 'GSK-3β' 作为标签的产品

1-Azakenpaullone

AR-A 014418

AZD1080

BIO-acetoxime

CHIR-99021

IM-12

LY2090314

SB 216763

SB 415286

TDZD-8

Tideglusib

TWS119

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