Thapsigargin

目录号: A14007

SERCA ATPase 抑制剂

Thapsigargin

Thapsigargin Chemical Structure

CAS NO. 67526-95-8

Thapsigargin是在Thapsia garganica的根中发现的一种细胞可渗透的倍半萜烯内酯。它是肿瘤的启动子,可通过抑制肌浆/内质网Ca2+ -ATPase(SERCA,IC50 = 30 nM)诱导细胞内储存的Ca2+释放,而不会水解肌醇磷脂。

库存: Discontinuted

规格 价格
5 mg
¥ 1,500.00
10 mg
¥ 2,500.00
25 mg
¥ 5,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Thapsigargin是在Thapsia garganica的根中发现的一种细胞可渗透的倍半萜烯内酯。它是肿瘤的启动子,可通过抑制肌浆/内质网Ca2+ -ATPase(SERCA,IC50 = 30 nM)诱导细胞内储存的Ca2+释放,而不会水解肌醇磷脂。
In vitro DMSO 93 mg/mL (142.9 mM)
Water 93 mg/mL (142.9 mM)
Ethanol 93 mg/mL (142.9 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.37 mL 76.83 mL 153.67 mL
0.5 mM 3.07 mL 15.37 mL 30.73 mL
1 mM 1.54 mL 7.68 mL 15.37 mL
5 mM 0.31 mL 1.54 mL 3.07 mL

*The above data is based on the productmolecular weight 650.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14007
作用机制 Inhibitor (抑制剂)
M. Wt 650.75
Formula C34H50O12
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 67526-95-8
SMILES CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

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