Trk Receptors

Inhibitory Selectivity

Catalog No.	Inhibitor Name	TrkA	TrkB	TrkC	Other
A11059	BMS-754807	**	***		Insulin Receptor,IGF-1R,Met
A16238	GW441756	****
A16259	Sitravatinib (MGCD516)	***	*		DDR2,EPHA3,Axl
A13877	ANA-12		*
A13730	GNF-5837	**	*	**
A15801	Entrectinib (RXDX-101)				ALK,ROS1
A10053	Tyrphostin AG 879	*			Her2
A10715	Danusertib (PHA-739358)	*			Aurora A, Abl, RET, FGFR1, Aurora C, Aurora B
A15494	LM22A-4		*
A15974	Larotrectinib (LOXO-101) sulfate
A16123	7,8-Dihydroxyflavone

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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LM22A-4

Catalog No. A15494
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TrkB 激动剂

LM22A-4是有效的原肌球蛋白相关激酶B（TrkB）激动剂（IC50 = 47 nM）。了解更多

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7,8-Dihydroxyflavone

Catalog No. A16123
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TrkB 激动剂

7,8-Dihydroxyflavone是一种选择性的酪氨酸激酶受体B（神经营养因子/原肌球蛋白受体激酶B；TrkB）激动剂，可用于帮助识别和区分由TrkB激活介导的生理效应和细胞信号通路。涉及神经保护，记忆，血管舒张和高血压。了解更多

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