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TRV130 (Oliceridine)

??-opioid receptor 激动剂

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产品目录号: A14337

库存状态:中国现货中国现货

产品名 目录号 价格 数量
TRV130 5mg A14337-5
¥ 1,600.00
TRV130 10mg A14337-10
¥ 2,800.00
TRV130 25mg A14337-25
¥ 5,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.

TRV130 (Oliceridine)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 TRV130 (Oliceridine) 发表的文献 (2)
  • Yevgen Yudin, .et al. The G protein-biased PZM21 and TRV130 act as partial agonists of 米-opioid receptors signaling to ion channel targets, bioRxiv, 2018, 2018
  • Araldi D, .et al. Mu-Opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat, Neuroscience, 2018, Dec 1; 394: 60每71 PMID: 30342200

Chemical Information

目录号 A14337
Mechanism of action Agonist
分子量 423.01
化学分子式 C22H31ClN2O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1401028-24-7
Synonyms TRV 130, TRV-130
SMILES code COC1=C(SC=C1)CNCC[C@]2(CCOC3(C2)CCCC3)C4=CC=CC=N4
化学名称 (R)-N-((3-methoxythiophen-2-yl)methyl)-2-(9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)ethanamine hydrochloride

生物活性

Description
TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less ??-arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.64 mL 118.2 mL 236.4mL
0.5 mM 4.73 mL 23.64 mL 47.28 mL
1 mM 2.36 mL 11.82 mL 23.64 mL
5 mM 0.47 mL 2.36 mL 4.73 mL

*The above data is based on the productmolecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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