PLX-4720

Catalog No. A10002

PLX-4720是一种有效的，选择性的B-RafV600E抑制剂，无细胞试验中IC50为13 nM，同样有效地作用于c-Raf-1(Y340D和Y341D突变型)，作用于B-RafV600E比作用于野生型B-Raf选择性高10倍。

Technical details

Catalog Num	A10002
M. Wt	413.8
Formula	C17H14ClF2N3O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	918505-84-7
Synonyms	PLX4720
SMILES	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F

Biological Activity

Targets

Target	Value
C-Raf-1(Y340D/Y341D)	IC50: 6.7nM
B-Raf(V600E)	IC50: 13nM
BRK	IC50: 130nM
B-Raf	IC50: 160nM
FRK	IC50: 1.3μM
CSK	IC50: 1.5μM
Src	IC50: 1.7μM
FAK	IC50: 1.7μM
FGFR	IC50: 1.9μM
KDR	IC50: 2.3μM
HGK	IC50: 2.8μM
CSF-1R	IC50: 3.3μM
AuroraA	IC50: 3.4μM

Solubility *

In vitro (25°C)	DMSO	81 mg/mL (195.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.17 mL	120.83 mL	241.66 mL
0.5 mM	4.83 mL	24.17 mL	48.33 mL
1 mM	2.42 mL	12.08 mL	24.17 mL
5 mM	0.48 mL	2.42 mL	4.83 mL

*The above data is based on the productmolecular weight 413.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.