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癌症
心血管
内分泌
表观遗传学
免疫
信号传导
代谢
神经科学
炎症
呼吸系统
干细胞
跨膜输运

Catalog No. Product Name Application Information
A19021
AMG-510 (Sotorasib)
KRAS G12C covalent inhibitor
AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
A18712
MD-224
MDM2 degrader
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
A17217
Pelitrexol (AG-2037)
GARFT inhibitor
Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity.
A17216
BAY-876
GLUT1 抑制剂
BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in?vitro and high oral bioavailability in?vivo.
A17236
DC661
PPT1 inhibitor
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).
A17226
Mivebresib (ABBV-075)
BET inhibitor
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity.
A17220
NPI64
Protease inhibitor
NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease.
A17241
Autophinib
Autophagy inhibitor
Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
A17242
PSMA617 TFA
PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.
A17225
AZ304
dual BRAF 抑制剂
AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
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