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癌症
心血管
内分泌
表观遗传学
免疫
信号传导
代谢
神经科学
炎症
呼吸系统
干细胞
跨膜输运

Catalog No. Product Name Application Information
A19021
AMG-510 (Sotorasib)
KRAS G12C covalent inhibitor
AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
A18712
MD-224
MDM2 degrader
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
A17227
AG1295
PDGFR 抑制剂
AG1295 is a PDGF receptor specific inhibitor.
A17222
Ras-IN-3144
pan-RAS inhibitor
Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.
A17229
KC01
ABHD16A inhibitor
KC01 is a covalent inhibitor of ABHD16A.
A17218
MX1013
pan-caspase inhibitor
MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9.
A17232
PUN30119
PUN30119, also known as Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
A17239
CCT245737
CHK1 inhibitor
CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
A17235
SBI-115
GPCR19 antagonist
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
A17245
Firocoxib
COX-2 抑制剂
Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses.
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