AT9283

Catalog No. A10095

AT9283抑制极光激酶A和B，并靶向与骨髓细胞增殖相关的其他酪氨酸和丝氨酸/苏氨酸激酶。

Product Citations

Tomoya Takeda, .et al. AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor-sensitive and -resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B, Oncol Rep, 2020, August 18

Technical details

Catalog Num	A10095
M. Wt	381.4
Formula	C19H23N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	896466-04-9
Synonyms
SMILES	C1CC1NC(=O)NC\2=CNN/C2=C\3/N=C4C=CC(=CC4=N3)CN5CCOCC5

Biological Activity

AT9283抑制极光激酶A和B，并靶向与骨髓细胞增殖相关的其他酪氨酸和丝氨酸/苏氨酸激酶。

Targets

Target	Value
JAK3	IC50: 1.1nM
JAK2	IC50: 1.2nM
AuroraA	IC50: ~3.0nM
AuroraB	IC50: ~3.0nM
Abl1(T315I)	IC50: 4nM
GSK-3β	IC50: 1nM-10nM
FGFR2	IC50: 1-10nM
VEGFR3/FLT4	IC50: 1nM-10nM
Mer	IC50: 1nM-10nM
RET	IC50: 1nM-10nM
RSK2	IC50: 1nM-10nM
RSK3	IC50: 1nM-10nM
TYK2	IC50: 1nM-10nM
YES	IC50: 1nM-10nM
Abl(Q252H)	IC50: 10nM-30nM
DRAK1	IC50: 10nM-30nM
FGFR1	IC50: 10nM-30nM
FGFR1(V561M)	IC50: 10nM-30nM
FGFR2(N549H)	IC50: 10nM-30nM
FGFR3	IC50: 10nM-30nM
VEGFR1/FLT1	IC50: 10nM-30nM
FLT3	IC50: 10nM-30nM
PDGFRα(D842V)	IC50: 10nM-30nM
PDK-1	IC50: 10nM-30nM
PKCμ	IC50: 10nM-30nM
RSK4	IC50: 10nM-30nM
Src(T341M)	IC50: 10nM-30nM
VEGFR2	IC50: 10nM-30nM

Solubility *

In vitro (25°C)	DMSO	68 mg/mL (178.28 mM)
	Water	Insoluble
	Ethanol	34 mg/mL (89.13 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.22 mL	131.1 mL	262.19 mL
0.5 mM	5.24 mL	26.22 mL	52.44 mL
1 mM	2.62 mL	13.11 mL	26.22 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

*The above data is based on the productmolecular weight 381.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.