Axitinib

Catalog No. A10103

Axitinib是一种小分子酪氨酸激酶抑制剂，可抑制多种靶标，包括VEGFR-1，VEGFR-2，VEGFR-3，血小板衍生生长因子受体（PDGFR）和cKIT（CD117）。

Product Citations

Youcef M. Rustum, .et al. Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy, Int J Mol Sci, 2018, Nov; 19(11): 3378 PMID: 30380599

Technical details

Catalog Num	A10103
M. Wt	386.5
Formula	C22H18N4OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	319460-85-0
Synonyms	AG 013736
SMILES	CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

Biological Activity

Axitinib是一种小分子酪氨酸激酶抑制剂，可抑制多种靶标，包括VEGFR-1，VEGFR-2，VEGFR-3，血小板衍生生长因子受体（PDGFR）和cKIT（CD117）。

Targets

Target	Value
VEGFR1/FLT1	IC50: 0.1nM
VEGFR2/Flk1	IC50: 0.18nM
VEGFR2/KDR	IC50: 0.2nM
VEGFR3	IC50: 0.1nM-0.3nM
PDGFRβ	IC50: 1.6nM
Kit	IC50: 1.7nM
PDGFRα	IC50: 5.0nM
CSF-1R	IC50: 73nM
FLT3	IC50: >1μM

Solubility *

In vitro	DMSO	Warmed: 30 mg/mL (77.62 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.87 mL	129.37 mL	258.73 mL
0.5 mM	5.17 mL	25.87 mL	51.75 mL
1 mM	2.59 mL	12.94 mL	25.87 mL
5 mM	0.52 mL	2.59 mL	5.17 mL

*The above data is based on the productmolecular weight 386.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.