Doramapimod (BIRB-796)

Catalog No. A10148

Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。

Product Citations

Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019

Technical details

Catalog Num	A10148
M. Wt	527.7
Formula	C31H37N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	285983-48-4
Synonyms	BIRB-796,BIRB 796
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

Biological Activity

Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。

Targets

p38α (Cell-free assay)	p38α
0.1 nM(Kd)	38 nM

Solubility *

In vitro (25°C)	DMSO	99 mg/mL (187.61 mM)
	Water	Insoluble
	Ethanol	99 mg/mL (187.61 mM)
In vivo	5% DMSO+40%PEG300+5%Tween80??+50%H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.95 mL	94.75 mL	189.5 mL
0.5 mM	3.79 mL	18.95 mL	37.9 mL
1 mM	1.9 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.9 mL	3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.