Celastrol
Catalog No. A10192
Celastrol是一种有效的蛋白酶抑制剂,有效且优先抑制胰凝乳蛋白酶样的纯化的20S proteasome的活性,IC50为2.5 μM。
- R. San Gil, .et al. Neurodegenerative disease-associated protein aggregates are poor inducers 2 of the heat shock response in neuronal-like cells, bioRxiv, 2020, Jan
- Abdin AA, .et al. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing-remitting model of multiple sclerosis in rats., Eur J Pharmacol., 2014, 742:102-12 PMID: 25218987
Catalog Num | A10192 |
---|---|
M. Wt | 450.6 |
Formula | C29H38O4 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 34157-83-0 |
Synonyms | |
SMILES | CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O |
Celastrol是一种有效的蛋白酶抑制剂,有效且优先抑制胰凝乳蛋白酶样的纯化的20S proteasome的活性,IC50为2.5 μM。
Targets
20S proteasome | 20S proteasome | |||
N/A | 2.5 μM |
In vitro | DMSO | 82 mg/mL (181.97 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.19 mL | 110.96 mL | 221.93 mL |
0.5 mM | 4.44 mL | 22.19 mL | 44.39 mL |
1 mM | 2.22 mL | 11.1 mL | 22.19 mL |
5 mM | 0.44 mL | 2.22 mL | 4.44 mL |
*The above data is based on the productmolecular weight 450.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.