Dapagliflozin (BMS512148)
Catalog No. A10285
Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白(SGLT2)的亚型2,后者负责肾脏中至少90%的葡萄糖重吸收。
- David Papadopoli, .et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin, Neoplasia, 2021, Apr;23(4):391-399 PMID: 33784591
- Neil Tanday, .et al. Dapagliflozin exerts positive effects on beta cells, decreases glucagon and does not alter beta- to alpha-cell transdifferentiation in mouse models of diabetes and insulin resistance, Biochem Pharmacol, 2020, Jul;177:114009 PMID: 32360307
- Subramaniam M, .et al. Comparison of Intestinal Glucose Flux and Electrogenic Current Demonstrates Two Absorptive Pathways in Pig and One in Nile Tilapia and Rainbow Trout, Am J Physiol Regul Integr Comp Physiol, 2019, Nov 20 PMID: 31746628
- Marina Subramaniam, .et al. Sigmoidal kinetics define porcine intestinal segregation of electrogenic monosaccharide transport systems as having multiple transporter population involvement, Physiol Rep, 2019, May; 7(9): e14090 PMID: 31062524
- Angelopoulou A, .et al. Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies, AAPS PharmSciTech, 2018, Feb;19(2):621-633 PMID: 8924948
Catalog Num | A10285 |
---|---|
M. Wt | 408.9 |
Formula | C21H25ClO6 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 461432-26-8 |
Synonyms | BMS512148, BMS-512148 |
SMILES | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl |
Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白(SGLT2)的亚型2,后者负责肾脏中至少90%的葡萄糖重吸收。
In vitro (25°C) | DMSO | 75 mg/mL (183.43 mM) | |
Water | Insoluble | ||
Ethanol | 15 mg/mL (36.68 mM) | ||
In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 3.8 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.46 mL | 122.28 mL | 244.56 mL |
0.5 mM | 4.89 mL | 24.46 mL | 48.91 mL |
1 mM | 2.45 mL | 12.23 mL | 24.46 mL |
5 mM | 0.49 mL | 2.45 mL | 4.89 mL |
*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.