Dexamethasone

Catalog No. A10299

Dexamethasone是一类固醇药物的糖皮质激素类的有效合成成员。它起着抗炎和免疫抑制剂的作用。它的功效约为天然激素氢化可的松的20-30倍，是泼尼松的4-5倍。

Product Citations

Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967

Technical details

Catalog Num	A10299
M. Wt	392.5
Formula	C22H29FO5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	CAS: 50-02-2
Synonyms	Decadron
SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (186 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (15.28 mM)
In vivo	5% DMSO+45% PEG 300+H2O	12 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.39 mL	254.78 mL
0.5 mM	5.1 mL	25.48 mL	50.96 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Dexamethasone

Product Citations

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions