Epothilone A

Catalog No. A10359

Epothilone A 通过稳定紫杉醇结合位点处的微管形成而起作用，并导致细胞周期停滞在G2/M转变，从而导致细胞毒性。

Technical details

Catalog Num	A10359
M. Wt	493.7
Formula	C26H39NO6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	152044-53-6
Synonyms	EpoA, Epothilone-A
SMILES	C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C

Biological Activity

Epothilone A 通过稳定紫杉醇结合位点处的微管形成而起作用，并导致细胞周期停滞在G2/M转变，从而导致细胞毒性。

Targets

Tubulin
2 μM(EC0.01)

Solubility *

In vitro	DMSO	92 mg/mL (186.36 mM)
	Water	Insoluble
	Ethanol	92 mg/mL (186.36 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.26 mL	101.28 mL	202.55 mL
0.5 mM	4.05 mL	20.26 mL	40.51 mL
1 mM	2.03 mL	10.13 mL	20.26 mL
5 mM	0.41 mL	2.03 mL	4.05 mL

*The above data is based on the productmolecular weight 493.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.