Fludarabine Phosphate (Fludara)

Catalog No. A10395

Fludarabine Phosphate (Fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。氟达拉滨通过干扰核糖核苷酸还原酶和dna聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。

Technical details

Catalog Num	A10395
M. Wt	365.2
Formula	C10H13FN5O7P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	75607-67-9
Synonyms
SMILES	O[C@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(F)nc2N)COP(=O)(O)O

Biological Activity

Targets

DNA polymerase α	DNA polymerase δ
1.1 μM(Ki )	1.3 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	66 mg/mL (180.71 mM)
	Water	Warmed: 2 mg/mL (5.47 mM)
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.38 mL	136.91 mL	273.82 mL
0.5 mM	5.48 mL	27.38 mL	54.76 mL
1 mM	2.74 mL	13.69 mL	27.38 mL
5 mM	0.55 mL	2.74 mL	5.48 mL

*The above data is based on the productmolecular weight 365.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.