FTY720 (Fingolimod)

Catalog No. A10408

FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物，ISP-1是中国草药Iscaria sinclarii的真菌代谢物，也是鞘氨醇的结构类似物。

Product Citations

Tina Sepasi, .et al. Targeted gene delivery to the brain using CDX-modified chitosan nanoparticles, BioImpacts, 2022, 28 May
Zengzi Zhou, .et al. Effects of immunomodulatory drug Fingolimod (FTY720) on Chlamydia dissemination and pathogenesis, Infect Immun, 2020, Oct 19;88(11):e00281-20 PMID: 32868341
Mayu Idehara, .et al. Inulooligosaccharides in Atractylodis lanceae rhizoma and Atractylodis rhizoma of hochuekkito formula are essential for regulation of the pulmonary immune system of immuno-compromised mice, Traditional & Kampo Medicine, 2020, 22 July
Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790
Sakai Y, .et al. Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system, Int J Biol Macromol, 2018, Nov 22;124:505-514 PMID: 30471397

Technical details

Catalog Num	A10408
M. Wt	343.9
Formula	C19H33NO2.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	162359-56-0
Synonyms	Gilenia
SMILES	CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

Biological Activity

FTY720 (Fingolimod)是ISP-1(肉豆蔻酸)的衍生物，ISP-1是中国草药Iscaria sinclarii的真菌代谢物，也是鞘氨醇的结构类似物。

Targets

S1P receptor (K562, NK cells )
0.033 nM

Solubility *

In vitro (25°C)	DMSO	64 mg/mL (186.09 mM)
	Water	64 mg/mL (186.09 mM)
	Ethanol	64 mg/mL (186.09 mM)
In vivo	Saline	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.08 mL	145.39 mL	290.78 mL
0.5 mM	5.82 mL	29.08 mL	58.16 mL
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL

*The above data is based on the productmolecular weight 343.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.