Irbesartan (Avapro)

Catalog No. A10477

Irbesartan (Avapro)是一种血管紧张素II受体拮抗剂，IC50为1.3 nM，主要用于治疗高血压。

Technical details

Catalog Num	A10477
M. Wt	428.5
Formula	C25H28N6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	138402-11-6
Synonyms	BMS-186295, SR-47436, Aprovel, Karvea, BMS186295
SMILES	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

Biological Activity

Irbesartan (Avapro)是一种血管紧张素II受体拮抗剂，IC50为1.3 nM，主要用于治疗高血压。

Targets

AT1 receptor
1.3 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 3 mg/mL (7 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (7 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.69 mL	233.37 mL
0.5 mM	4.67 mL	23.34 mL	46.67 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.