Ki16425
Catalog No. A10501
ki16425是对LPA1和LPA3具有选择性的LPA受体拮抗剂,对人LPA1、LPA2和LPA3受体分别显示Ki值为0.34、6.5和0.93 μM。
- Maria F Fernandes, .et al. Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid, Int J Mol Sci, 2022, Apr 9;23(8):4163 PMID: 35456981
- Rieko Suenaga, .et al. Lateral access mechanism of LPA receptor probed by molecular dynamics simulation, PLoS One, 2022, Feb 3;17(2):e0263296 PMID: 35113924
- Inoue A, .et al. Illuminating G-Protein-Coupling Selectivity of GPCRs, Cell, 2019, Jun 13;177(7):1933-1947 PMID: 31160049
- Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
- T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
Catalog Num | A10501 |
---|---|
M. Wt | 475.0 |
Formula | C23H23ClN2O5S |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 355025-24-0 |
Synonyms | Ki 16425, Ki-16425 |
SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O |
ki16425是对LPA1和LPA3具有选择性的LPA受体拮抗剂,对人LPA1、LPA2和LPA3受体分别显示Ki值为0.34、6.5和0.93 μM。
In vitro (25°C) | DMSO | 85 mg/mL (178.96 mM) | |
Water | Insoluble | ||
Ethanol | 85 mg/mL (178.96 mM) | ||
In vivo | 5% DMSO+95% Corn oil | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.05 mL | 105.26 mL | 210.53 mL |
0.5 mM | 4.21 mL | 21.05 mL | 42.11 mL |
1 mM | 2.11 mL | 10.53 mL | 21.05 mL |
5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
*The above data is based on the productmolecular weight 475.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.