Leflunomide

Catalog No. A10521

Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。

Technical details

Catalog Num	A10521
M. Wt	270.2
Formula	C12H9F3N2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	75706-12-6
Synonyms	Arava
SMILES	CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

Biological Activity

Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。

Targets

Dihydroorotate dehydrogenase

Solubility *

In vitro	DMSO	49 mg/mL (181.34 mM)
	Water	Insoluble
	Ethanol	49 mg/mL (181.34 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.01 mL	185.05 mL	370.1 mL
0.5 mM	7.4 mL	37.01 mL	74.02 mL
1 mM	3.7 mL	18.5 mL	37.01 mL
5 mM	0.74 mL	3.7 mL	7.4 mL

*The above data is based on the productmolecular weight 270.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.