LY2228820 (Ralimetinib)

Catalog No. A10545

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。

Technical details

Catalog Num	A10545
M. Wt	612.7
Formula	C24H29FN6.2CH4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	862507-23-1
Synonyms	LY-2228820
SMILES	CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O

Biological Activity

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。

Targets

p38α (Cell-free assay)
7 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (6.52 mM)
	Water	Warmed: 91 mg/mL (148.51 mM)
	Ethanol	3 mg/mL (4.89 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.32 mL	81.61 mL	163.21 mL
0.5 mM	3.26 mL	16.32 mL	32.64 mL
1 mM	1.63 mL	8.16 mL	16.32 mL
5 mM	0.33 mL	1.63 mL	3.26 mL

*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.