Manidipine 2HCl

Catalog No. A10554

Manidipine dihydrochloride是Manidipine的HCl盐形式，Manidipine是Ca2+电流的钙通道阻滞剂，IC50为2.6 nM。

Product Citations

Noriaki Ikemura,, .et al. Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine, Chem -Biol Interact, 2019, 306:1-9

Technical details

Catalog Num	A10554
M. Wt	683.6
Formula	C35H40Cl2N4O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	89226-75-5
Synonyms	CV-4093
SMILES	CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl

Biological Activity

Manidipine dihydrochloride是Manidipine的HCl盐形式，Manidipine是Ca2+电流的钙通道阻滞剂，IC50为2.6 nM。

Targets

Calcium channel
2.6 nM

Solubility *

In vitro (25°C)	DMSO	19 mg/mL (27.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.63 mL	73.14 mL	146.28 mL
0.5 mM	2.93 mL	14.63 mL	29.26 mL
1 mM	1.46 mL	7.31 mL	14.63 mL
5 mM	0.29 mL	1.46 mL	2.93 mL

*The above data is based on the productmolecular weight 683.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.