Masitinib ( AB1010)

Catalog No. A10558

Masitinib (AB1010)是一种蛋白质酪氨酸激酶抑制剂。

Product Citations

S Masson ,etc. Inhibition of Cell Signalling in Neoplastic Canine Mast Cells. , 2014, .

Technical details

Catalog Num	A10558
M. Wt	498.6
Formula	C28H30N6OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	790299-79-5
Synonyms	AB1010, Masivet
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

Biological Activity

Masitinib (AB1010)是一种蛋白质酪氨酸激酶抑制剂。

Targets

Target	Value
Kit	IC50: 200nM
LynB	IC50: 510nM
PDGFRα	IC50: 540nM
PDGFRβ	IC50: 800nM
Abl1	IC50: 1.20μM
c-Fms	IC50: 1.48μM
Src	IC50: 1.87μM
Hck	IC50: 2.0μM
FLT3	IC50: >10μM
VEGFR1	IC50: >10μM
VEGFR2	IC50: >10μM
EGFR	IC50: >10μM
FGFR1	IC50: >10μM
FGFR3	IC50: >10μM
IGF-1R	IC50: >10μM
c-Met	IC50: >10μM
c-Ret	IC50: >10μM
JAK2	IC50: >10μM
BTK	IC50: >10μM
Bmx	IC50: >10μM
Syk	IC50: >10μM
Fes	IC50: >10μM
PKCα	IC50: >10μM
Pim1	IC50: >10μM
Akt1	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (182.49 mM)
	Water	Insoluble
	Ethanol	4 mg/mL
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.28 mL	200.56 mL
0.5 mM	4.01 mL	20.06 mL	40.11 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.