OSI-420

Catalog No. A10678

OSI-420 (Desmethyl Erlotinib,CP-473420)是一种口服活性EGFR酪氨酸激酶抑制剂，可通过抑制细胞间结构域来抑制受体酪氨酸激酶（TKs）。

Product Citations

Yuta Yamamoto, .et al. Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay, J Pharm Anal, 2018, Apr; 8(2): 119-123 PMID: 29736298
Janet L. Martin, .et al. Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade, Breast Cancer Res, 2017, 19: 90 PMID: 28778177

Technical details

Catalog Num	A10678
M. Wt	415.9
Formula	C21H21N3O4.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	183320-51-6
Synonyms	Desmethyl Erlotinib,CP-473420, OSI420
SMILES	COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO.Cl

Biological Activity

OSI-420 (Desmethyl Erlotinib,CP-473420)是一种口服活性EGFR酪氨酸激酶抑制剂，可通过抑制细胞间结构域来抑制受体酪氨酸激酶（TKs）。

Targets

EGFR
2 nM

Solubility *

In vitro	DMSO	Warmed: 75 mg/mL (180.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.04 mL	120.22 mL	240.44 mL
0.5 mM	4.81 mL	24.04 mL	48.09 mL
1 mM	2.4 mL	12.02 mL	24.04 mL
5 mM	0.48 mL	2.4 mL	4.81 mL

*The above data is based on the productmolecular weight 415.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.