PCI-24781 (Abexinostat)

Catalog No. A10700

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。

Technical details

Catalog Num	A10700
M. Wt	397.4
Formula	C21H23N3O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	783355-60-2
Synonyms	PCI24781, CRA-024781
SMILES	CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO

Biological Activity

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。

Targets

Target	Value
HDAC1	ki: 7nM
HDAC3/SMRT	ki: 8.2nM
HDAC6	ki: 17nM
HDAC2	ki: 19nM
HDAC10	IC50: 24nM
HDAC8	IC50: 280nM

Solubility *

In vitro	DMSO	72 mg/mL (181.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.16 mL	125.82 mL	251.64 mL
0.5 mM	5.03 mL	25.16 mL	50.33 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.