PF-04217903

Catalog No. A10711

PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。

Technical details

Catalog Num	A10711
M. Wt	372.4
Formula	C19H16N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	956905-27-4
Synonyms	PF04217903
SMILES	C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1

Biological Activity

PF-04217903是一种选择性的，ATP竞争性c-Met抑制剂，在A549细胞中IC50为4.8 nM，对致癌基因突变型敏感(对Y1230C突变型没有活性)。

Targets

c-Met (A549 cells)
4.8 nM

Solubility *

In vitro (25°C)	DMSO	5 mg/mL (13.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.85 mL	134.26 mL	268.53 mL
0.5 mM	5.37 mL	26.85 mL	53.71 mL
1 mM	2.69 mL	13.43 mL	26.85 mL
5 mM	0.54 mL	2.69 mL	5.37 mL

*The above data is based on the productmolecular weight 372.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.