Posaconazole

Catalog No. A10744

Posaconazole主要是CYP3A4的抑制剂，但不抑制其他CYP酶的活性。也是甾醇C14+脱甲基酶抑制剂的抑制剂，IC50为0.25μM。泊沙康唑的终末消除半衰期中位数为15-35小时。

Technical details

Catalog Num	A10744
M. Wt	700.8
Formula	C37H42F2N8O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	171228-49-2
Synonyms	Noxafil
SMILES	CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

Biological Activity

Targets

lanosterol 14α-demethylase

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (128.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.27 mL	71.35 mL	142.69 mL
0.5 mM	2.85 mL	14.27 mL	28.54 mL
1 mM	1.43 mL	7.13 mL	14.27 mL
5 mM	0.29 mL	1.43 mL	2.85 mL

*The above data is based on the productmolecular weight 700.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.