Ramelteon (TAK-375)
Catalog No. A10777
Ramelteon (TAK-375)是melatonin受体激动剂,对褪黑激素MT1(IC50 = 28.5±8.55 pM)和MT2(20.1±9.25 pM)受体均具有高亲和力,并且相对于MT3受体具有选择性。
Catalog Num | A10777 |
---|---|
M. Wt | 259.3 |
Formula | C16H21NO2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 196597-26-9 |
Synonyms | Rozerem, TAK-375, TAK375 |
SMILES | CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3 |
Ramelteon (TAK-375)是melatonin受体激动剂,对褪黑激素MT1(IC50 = 28.5±8.55 pM)和MT2(20.1±9.25 pM)受体均具有高亲和力,并且相对于MT3受体具有选择性。
Targets
MT1 receptor | MT receptor (chicken) | MT2 receptor | ||
14 pM(Ki) | 23.1 pM(Ki) | 112 pM(Ki) |
In vitro (25°C) | DMSO | 47 mg/mL (181.22 mM) | |
Water | Insoluble | ||
Ethanol | 47 mg/mL (181.22 mM) | ||
In vivo | 0.5% methylcellulose | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 38.57 mL | 192.83 mL | 385.65 mL |
0.5 mM | 7.71 mL | 38.57 mL | 77.13 mL |
1 mM | 3.86 mL | 19.28 mL | 38.57 mL |
5 mM | 0.77 mL | 3.86 mL | 7.71 mL |
*The above data is based on the productmolecular weight 259.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.