RO4929097

Catalog No. A10802

RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。

Product Citations

Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Technical details

Catalog Num	A10802
M. Wt	469.4
Formula	C22H20F5N3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	847925-91-1
Synonyms
SMILES	CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

Biological Activity

RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。

Targets

γ secretase (Cell-free assay)	γ secretase(ICN) (Cell-free assay)	Aβ40 (Cell-free assay)
4 nM	5 nM	14 nM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (195.99 mM)
	Water	Insoluble
	Ethanol	16 mg/mL
In vivo	2% DMSO+30% PEG 300+5% Tween+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.3 mL	106.52 mL	213.04 mL
0.5 mM	4.26 mL	21.3 mL	42.61 mL
1 mM	2.13 mL	10.65 mL	21.3 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.