SGI-1776 (free base)

Catalog No. A10838

SGI-1776 (free base)是Pim1的一种新型ATP竞争性抑制剂，在无细胞试验中的IC50为7 nM，选择性是Pim2和Pim3的50倍和10倍，对Flt3和haspin也有效。阶段1。

Product Citations

Ishikawa C, .et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639

Technical details

Catalog Num	A10838
M. Wt	405.4
Formula	C20H22F3N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1025065-69-3
Synonyms	SGI1776
SMILES	CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

Biological Activity

SGI-1776 (free base)是Pim1的一种新型ATP竞争性抑制剂，在无细胞试验中的IC50为7 nM，选择性是Pim2和Pim3的50倍和10倍，对Flt3和haspin也有效。阶段1。

Solubility *

In vitro (25°C)	DMSO	70 mg/mL (172.66 mM)
	Water	Insoluble
	Ethanol	70 mg/mL (172.66 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.67 mL	123.33 mL	246.67 mL
0.5 mM	4.93 mL	24.67 mL	49.33 mL
1 mM	2.47 mL	12.33 mL	24.67 mL
5 mM	0.49 mL	2.47 mL	4.93 mL

*The above data is based on the productmolecular weight 405.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.