TSU-68 (Orantinib, SU6668)

Catalog No. A10953

TSU-68 (Orantinib,SU6668)在无细胞试验中具有8 nM的Ki对PDGFR自磷酸化的最大效力，但也强烈抑制Flk-1和FGFR1反磷酸化，对IGF-1R，Met，Src， Lck，Zap70，Abl和CDK2；不抑制EGFR。

Product Citations

Aaron Y. Lai, .et al. Venular degeneration leads to vascular dysfunction in a transgenic model of Alzheimer's disease., Brain, 2015, Apr;138(Pt 4):1046-58 PMID: 25688079

Technical details

Catalog Num	A10953
M. Wt	310.4
Formula	C18H18N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	252916-29-3
Synonyms	TSU68
SMILES	CC1=C(NC(=C1CCC(=O)O)C)/C=C\2/C3=CC=CC=C3NC2=O

Biological Activity

Targets

PDGFRβ (Cell-free assay)	FGFR1 (Cell-free assay)	Flk1 (Cell-free assay)
8 nM(Ki)	1.2 μM(Ki)	2.1 μM(Ki)

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (177.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.22 mL	161.08 mL	322.16 mL
0.5 mM	6.44 mL	32.22 mL	64.43 mL
1 mM	3.22 mL	16.11 mL	32.22 mL
5 mM	0.64 mL	3.22 mL	6.44 mL

*The above data is based on the productmolecular weight 310.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.