VX-702

Catalog No. A10982

VX-702是一种高选择性p38α MAPK抑制剂，可抑制血小板激动剂诱导的p38激活（IC50 = 4至20 nM）。

Product Citations

Wei-Chun HuangFu, etc. Inflammatory signaling compromises cell responses to interferon alpha. Oncogene. 2012 Jan 12; 31(2): 161–172.

Technical details

Catalog Num	A10982
M. Wt	404.3
Formula	C19H12F4N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	479543-46-9, 745833-23-2
Synonyms	VX702, VX 702
SMILES	C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F

Biological Activity

VX-702是一种高选择性p38α MAPK抑制剂，可抑制血小板激动剂诱导的p38激活（IC50 = 4至20 nM）。

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (190.45 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.73 mL	123.67 mL	247.34 mL
0.5 mM	4.95 mL	24.73 mL	49.47 mL
1 mM	2.47 mL	12.37 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL

*The above data is based on the productmolecular weight 404.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.