VX-770 (Ivacaftor)

Catalog No. A10985

VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。

Product Citations

Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157

Technical details

Catalog Num	A10985
M. Wt	392.5
Formula	C24H28N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	873054-44-5, 121911-71-5
Synonyms	Kalydeco, VX770
SMILES	CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

Biological Activity

VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。

Targets

F508del-CFTR (Fisher rat thyroid cells)	G551D-CFTR (Fisher rat thyroid cells)
25 nM(EC50)	100 nM(EC50)

Solubility *

In vitro	DMSO	69 mg/mL (175.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.39 mL	254.78 mL
0.5 mM	5.1 mL	25.48 mL	50.96 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.