AMG-458

Catalog No. A11055

AMG-458是一种有效的c-Met抑制剂，IC50值为60nM，对VEGFR2具有选择性。

Technical details

Catalog Num	A11055
M. Wt	539.6
Formula	C30H29N5O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	913376-83-7
Synonyms	AMG458, AMG 458
SMILES	CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

Biological Activity

AMG-458是一种有效的c-Met抑制剂，IC50值为60nM，对VEGFR2具有选择性。

Targets

Target	Value
c-Met(H1094R)	ki: 0.5nM
c-Met(V1092I)	ki: 1.1nM
c-Met(Human)	ki: 1.2nM
c-Met(Mouse)	ki: 2.0nM
c-Met(D1228H)	ki: 2.2nM
c-Met(M1250T)	ki: 4.1nM
c-Met(Y1230H)	ki: 4.5nM
VEGFR2	ki: 4.1μM

Solubility *

In vitro (25°C)	DMSO	18 mg/mL (33.35 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol+citrate vehicle	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.66 mL	185.32 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.