Fadrozole

Catalog No. A11088

Fadrozole是一种非甾体芳香化酶抑制剂，在体内和体内雌激素的生物合成中均表现出非常有效和选择性的抑制作用。

Product Citations

Steve U. Ayobahan, .et al. A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure, Sci Rep, 2019, 9, Article number: 6599
Muth-Köhne E, .et al. Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test, Aquat Toxicol, 2016, Jul;176:116-27 PMID: 27130971
Ma YN, .et al. Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio), Aquat Toxicol, 2016, Oct;179:55-64 PMID: 27571716

Technical details

Catalog Num	A11088
M. Wt	223.27
Formula	C14H13N3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	102676-47-1
Synonyms
SMILES	C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N

Biological Activity

Fadrozole是一种非甾体芳香化酶抑制剂，在体内和体内雌激素的生物合成中均表现出非常有效和选择性的抑制作用。

Solubility *

In vitro	DMSO	42 mg/mL (188.1 mM)
	Water	Insoluble
	Ethanol	42 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	44.79 mL	223.94 mL	447.89 mL
0.5 mM	8.96 mL	44.79 mL	89.58 mL
1 mM	4.48 mL	22.39 mL	44.79 mL
5 mM	0.9 mL	4.48 mL	8.96 mL

*The above data is based on the productmolecular weight 223.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.