PAC-1

Catalog No. A11090

PAC-1是procaspase-3的激活剂，可诱导癌细胞凋亡，EC50为2.08μM。

Product Citations

Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Technical details

Catalog Num	A11090
M. Wt	392.5
Formula	C23H28N4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	315183-21-2
Synonyms	PAC1,first procaspase activating compound
SMILES	C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O

Biological Activity

PAC-1是procaspase-3的激活剂，可诱导癌细胞凋亡，EC50为2.08μM。

Targets

Procaspase-3
0.22 μM(EC50)

Solubility *

In vitro (25°C)	DMSO	75 mg/mL (191.09 mM)
	Water	Insoluble
	Ethanol	15 mg/mL (38.21 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.39 mL	254.78 mL
0.5 mM	5.1 mL	25.48 mL	50.96 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.