INCB28060

Catalog No. A11132

INCB28060 (Capmatinib )是一种新型的，ATP竞争性c-MET抑制剂，无细胞试验中IC50为0.13 nM，对RONβ，EGFR和HER-3无活性。

Product Citations

Wei Deying,etc. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Biosci Rep. 2017 Apr 30; 37(2): BSR20160470.

Technical details

Catalog Num	A11132
M. Wt	412.4
Formula	C23H17FN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1029712-80-8
Synonyms	INCB-28060, INC-280, INC280
SMILES	CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

Biological Activity

INCB28060 (Capmatinib )是一种新型的，ATP竞争性c-MET抑制剂，无细胞试验中IC50为0.13 nM，对RONβ，EGFR和HER-3无活性。

Targets

c-Met (Cell-free assay)
0.13 nM

Solubility *

In vitro	DMSO	2 mg/mL (4.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.25 mL	121.24 mL	242.48 mL
0.5 mM	4.85 mL	24.25 mL	48.5 mL
1 mM	2.42 mL	12.12 mL	24.25 mL
5 mM	0.48 mL	2.42 mL	4.85 mL

*The above data is based on the productmolecular weight 412.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.