NPS-2143 (SB-262470)

Catalog No. A11140

NPS-2143 (SB-262470)是一种选择性的Ca2+感应受体拮抗剂，显示可阻止HEK293细胞中表达的人Ca2+受体引起的细胞质Ca2+浓度增加，IC50为43 nM。

Technical details

Catalog Num	A11140
M. Wt	408.9
Formula	C24H25ClN2O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	284035-33-2
Synonyms	NPS2143, SB262470
SMILES	CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O

Biological Activity

NPS-2143 (SB-262470)是一种选择性的Ca2+感应受体拮抗剂，显示可阻止HEK293细胞中表达的人Ca2+受体引起的细胞质Ca2+浓度增加，IC50为43 nM。

Targets

Ca(2+) receptor
43 nM

Solubility *

In vitro (25°C)	DMSO	79 mg/mL (193.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.46 mL	122.28 mL	244.56 mL
0.5 mM	4.89 mL	24.46 mL	48.91 mL
1 mM	2.45 mL	12.23 mL	24.46 mL
5 mM	0.49 mL	2.45 mL	4.89 mL

*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.