PCI-34051

Catalog No. A11152

PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8（HDAC8）抑制剂，其选择性是其他HDAC亚型的200倍以上。

Technical details

Catalog Num	A11152
M. Wt	296.3
Formula	C17H16N2O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	950762-95-5
Synonyms	PCI34051
SMILES	COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO

Biological Activity

PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8（HDAC8）抑制剂，其选择性是其他HDAC亚型的200倍以上。

Targets

Target	Value
HDAC8	IC50: 10nM
HDAC6	IC50: 2.9μM
HDAC1	IC50: 4μM
HDAC10	IC50: 13μM
HDAC2	IC50: >50μM
HDAC3	IC50: >50μM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (195.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40%PEG300+5% tween80+50% H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.75 mL	168.75 mL	337.5 mL
0.5 mM	6.75 mL	33.75 mL	67.5 mL
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL

*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.