ARRY334543 (Varlitinib)

Catalog No. A11158

ARRY334543 (Varlitinib)是一种有效的EGFR和ErbB-2口服活性小分子抑制剂。

Product Citations

Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Technical details

Catalog Num	A11158
M. Wt	466.94
Formula	C22H19ClN6O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	845272-21-1
Synonyms	ARRY-334543, Varlitinib
SMILES	C1=CC=C(C=C1)C[N+]2=C(N=C(S2)NC3=CC=CC=C3)C4=CC=CC=C4

Biological Activity

ARRY334543 (Varlitinib)是一种有效的EGFR和ErbB-2口服活性小分子抑制剂。

Solubility *

In vitro	DMSO	6 mg/mL (12.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.42 mL	107.08 mL	214.16 mL
0.5 mM	4.28 mL	21.42 mL	42.83 mL
1 mM	2.14 mL	10.71 mL	21.42 mL
5 mM	0.43 mL	2.14 mL	4.28 mL

*The above data is based on the productmolecular weight 466.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.